Les IAP au cœur de la signalisation NF-κB

Jessy Cartier; Arthur Marivin; Jean Berthelet; Laurence Dubrez

doi:10.1051/medsci/2012281019

Les IAP au cœur de la signalisation NF-κB

Translated title of the contribution: IAPs: a central element in the NF-κB activating signaling pathway

Jessy Cartier, Arthur Marivin, Jean Berthelet, Laurence Dubrez

Research output: Contribution to journal › Literature review › peer-review

Abstract / Description of output

The function of IAP has long been limited to an inhibition of apoptosis through their capacity to bind some caspases. Since the expression of these proteins is altered in some tumor samples, IAPs are targets for anticancer therapy and many small molecules have been designed for their capacity to inhibit IAP-caspase interaction. Unexpectedly, these molecules appeared to significantly affect NF-κB activation. In this review, we will discuss the central role of cIAP1, cIAP2 and XIAP in the regulation of NF-κB activating signaling pathways.

Translated title of the contribution	IAPs: a central element in the NF-κB activating signaling pathway
Original language	French
Pages (from-to)	69-75
Number of pages	7
Journal	médecine/sciences
Volume	28
Issue number	1
DOIs	https://doi.org/10.1051/medsci/2012281019
Publication status	Published - Jan 2012

Keywords / Materials (for Non-textual outputs)

Animals
Antineoplastic Agents
Bone Morphogenetic Proteins
DNA Damage
Drosophila Proteins
Gene Expression Regulation
Humans
Immunity, Innate
Inhibitor of Apoptosis Proteins
Mammals
Models, Genetic
Molecular Targeted Therapy
Multigene Family
NF-kappa B
Neoplasm Proteins
Protein Structure, Tertiary
Receptors, Tumor Necrosis Factor
Signal Transduction
Structure-Activity Relationship
Transcription, Genetic
Transforming Growth Factor beta
Viral Proteins
X-Linked Inhibitor of Apoptosis Protein

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10.1051/medsci/2012281019

Cite this

@article{f47ebca626ea4443be87df765c045f9c,

title = "Les IAP au c{\oe}ur de la signalisation NF-κB",

abstract = "The function of IAP has long been limited to an inhibition of apoptosis through their capacity to bind some caspases. Since the expression of these proteins is altered in some tumor samples, IAPs are targets for anticancer therapy and many small molecules have been designed for their capacity to inhibit IAP-caspase interaction. Unexpectedly, these molecules appeared to significantly affect NF-κB activation. In this review, we will discuss the central role of cIAP1, cIAP2 and XIAP in the regulation of NF-κB activating signaling pathways.",

keywords = "Animals, Antineoplastic Agents, Bone Morphogenetic Proteins, DNA Damage, Drosophila Proteins, Gene Expression Regulation, Humans, Immunity, Innate, Inhibitor of Apoptosis Proteins, Mammals, Models, Genetic, Molecular Targeted Therapy, Multigene Family, NF-kappa B, Neoplasm Proteins, Protein Structure, Tertiary, Receptors, Tumor Necrosis Factor, Signal Transduction, Structure-Activity Relationship, Transcription, Genetic, Transforming Growth Factor beta, Viral Proteins, X-Linked Inhibitor of Apoptosis Protein",

author = "Jessy Cartier and Arthur Marivin and Jean Berthelet and Laurence Dubrez",

note = "{\textcopyright} 2012 m{\'e}decine/sciences – Inserm / SRMS.",

year = "2012",

month = jan,

doi = "10.1051/medsci/2012281019",

language = "French",

volume = "28",

pages = "69--75",

journal = "m{\'e}decine/sciences",

issn = "0767-0974",

publisher = "EDP Sciences",

number = "1",

}

TY - JOUR

T1 - Les IAP au cœur de la signalisation NF-κB

AU - Cartier, Jessy

AU - Marivin, Arthur

AU - Berthelet, Jean

AU - Dubrez, Laurence

PY - 2012/1

Y1 - 2012/1

N2 - The function of IAP has long been limited to an inhibition of apoptosis through their capacity to bind some caspases. Since the expression of these proteins is altered in some tumor samples, IAPs are targets for anticancer therapy and many small molecules have been designed for their capacity to inhibit IAP-caspase interaction. Unexpectedly, these molecules appeared to significantly affect NF-κB activation. In this review, we will discuss the central role of cIAP1, cIAP2 and XIAP in the regulation of NF-κB activating signaling pathways.

AB - The function of IAP has long been limited to an inhibition of apoptosis through their capacity to bind some caspases. Since the expression of these proteins is altered in some tumor samples, IAPs are targets for anticancer therapy and many small molecules have been designed for their capacity to inhibit IAP-caspase interaction. Unexpectedly, these molecules appeared to significantly affect NF-κB activation. In this review, we will discuss the central role of cIAP1, cIAP2 and XIAP in the regulation of NF-κB activating signaling pathways.

KW - Animals

KW - Antineoplastic Agents

KW - Bone Morphogenetic Proteins

KW - DNA Damage

KW - Drosophila Proteins

KW - Gene Expression Regulation

KW - Humans

KW - Immunity, Innate

KW - Inhibitor of Apoptosis Proteins

KW - Mammals

KW - Models, Genetic

KW - Molecular Targeted Therapy

KW - Multigene Family

KW - NF-kappa B

KW - Neoplasm Proteins

KW - Protein Structure, Tertiary

KW - Receptors, Tumor Necrosis Factor

KW - Signal Transduction

KW - Structure-Activity Relationship

KW - Transcription, Genetic

KW - Transforming Growth Factor beta

KW - Viral Proteins

KW - X-Linked Inhibitor of Apoptosis Protein

U2 - 10.1051/medsci/2012281019

DO - 10.1051/medsci/2012281019

M3 - Literature review

C2 - 22289833

SN - 0767-0974

VL - 28

SP - 69

EP - 75

JO - médecine/sciences

JF - médecine/sciences

IS - 1

ER -

Les IAP au cœur de la signalisation NF-κB

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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Cite this