Lesion correlates of auditory sentence comprehension deficits in post-stroke aphasia

Erica Adezati, Melissa Thye, Amelia Edmondson-Stait, Jerzy P. Szaflarski, Dan Mirman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Auditory sentence comprehension requires coordination of multiple levels of processing: auditory-phonological perception, lexical-semantic comprehension, syntactic parsing and discourse construction, as well as executive functions such as verbal working memory (WM) and cognitive control. This study examined the lesion correlates of sentence comprehension deficits in post-stroke aphasia, building on prior work on this topic by using a different and clinically-relevant measure of sentence comprehension (the Token Test) and multivariate (SCCAN) and connectome-based lesion-symptom mapping methods. The key findings were that lesions in the posterior superior temporal lobe and inferior frontal gyrus (pars triangularis) were associated with sentence comprehension deficits, which was observed in both mass univariate and multivariate lesion-symptom mapping. Graph theoretic measures of connectome disruption were not statistically significantly associated with sentence comprehension deficits after accounting for overall lesion size.
Original languageEnglish
Article number100076
Number of pages6
JournalNeuroimage: Reports
Volume2
Issue number1
Early online date4 Jan 2022
DOIs
Publication statusPublished - Mar 2022

Keywords / Materials (for Non-textual outputs)

  • aphasia
  • language comprehension
  • lesion-symptom mapping

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