Lessons from non-canonical splicing

Christopher R Sibley, Lorea Blazquez, Jernej Ule

Research output: Contribution to journalReview articlepeer-review

Abstract

Recent improvements in experimental and computational techniques that are used to study the transcriptome have enabled an unprecedented view of RNA processing, revealing many previously unknown non-canonical splicing events. This includes cryptic events located far from the currently annotated exons and unconventional splicing mechanisms that have important roles in regulating gene expression. These non-canonical splicing events are a major source of newly emerging transcripts during evolution, especially when they involve sequences derived from transposable elements. They are therefore under precise regulation and quality control, which minimizes their potential to disrupt gene expression. We explain how non-canonical splicing can lead to aberrant transcripts that cause many diseases, and also how it can be exploited for new therapeutic strategies.

Original languageEnglish
Pages (from-to)407-421
Number of pages15
JournalNature Reviews Genetics
Volume17
Issue number7
DOIs
Publication statusPublished - 31 May 2016

Keywords

  • Computational Biology/methods
  • Evolution, Molecular
  • Gene Expression Profiling
  • Humans
  • RNA Splicing/genetics
  • Sequence Analysis, RNA/methods
  • Transcriptome/genetics

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