LEUKOCYTES | Neutrophils

Katharine M. Lodge, Tyler Morrison, Andrew S. Cowburn, Sarah R. Walmlsey, Edwin R. Chilvers

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The neutrophil is a phagocytic leukocyte, the most abundant in the human body and the most short-lived of all myeloid cells. This polymorphonuclear cell is packed with granules containing potent antimicrobial compounds and is absolutely essential for day-to-day successful defense against bacterial and fungal infections. Its recruitment and activation are carefully regulated, and control of its life span coupled with mechanisms allowing for a noninflammatory death pathway (apoptosis) reduce risks of tissue damage and disease arising from unwanted neutrophil activation. Given their destructive potential, and despite intensive regulation of their function, it is unsurprising that neutrophilic inflammatory diseases are prevalent; these include asthma, chronic obstructive pulmonary disease, the acute respiratory distress syndrome, and several vasculitides.
Original languageEnglish
Title of host publicationReference Module in Biomedical Sciences
PublisherElsevier, London
DOIs
Publication statusPublished - 28 May 2020

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