LEUKOCYTES | Neutrophils

Katharine M. Lodge; Tyler Morrison; Andrew S. Cowburn; Sarah R. Walmlsey; Edwin R. Chilvers

doi:10.1016/B978-0-12-801238-3.11695-2

LEUKOCYTES | Neutrophils

Katharine M. Lodge, Tyler Morrison, Andrew S. Cowburn, Sarah R. Walmlsey, Edwin R. Chilvers

Royal (Dick) School of Veterinary Studies

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract / Description of output

The neutrophil is a phagocytic leukocyte, the most abundant in the human body and the most short-lived of all myeloid cells. This polymorphonuclear cell is packed with granules containing potent antimicrobial compounds and is absolutely essential for day-to-day successful defense against bacterial and fungal infections. Its recruitment and activation are carefully regulated, and control of its life span coupled with mechanisms allowing for a noninflammatory death pathway (apoptosis) reduce risks of tissue damage and disease arising from unwanted neutrophil activation. Given their destructive potential, and despite intensive regulation of their function, it is unsurprising that neutrophilic inflammatory diseases are prevalent; these include asthma, chronic obstructive pulmonary disease, the acute respiratory distress syndrome, and several vasculitides.

Original language	English
Title of host publication	Reference Module in Biomedical Sciences
Publisher	Elsevier
DOIs	https://doi.org/10.1016/B978-0-12-801238-3.11695-2
Publication status	Published - 28 May 2020

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title = "LEUKOCYTES | Neutrophils",

abstract = "The neutrophil is a phagocytic leukocyte, the most abundant in the human body and the most short-lived of all myeloid cells. This polymorphonuclear cell is packed with granules containing potent antimicrobial compounds and is absolutely essential for day-to-day successful defense against bacterial and fungal infections. Its recruitment and activation are carefully regulated, and control of its life span coupled with mechanisms allowing for a noninflammatory death pathway (apoptosis) reduce risks of tissue damage and disease arising from unwanted neutrophil activation. Given their destructive potential, and despite intensive regulation of their function, it is unsurprising that neutrophilic inflammatory diseases are prevalent; these include asthma, chronic obstructive pulmonary disease, the acute respiratory distress syndrome, and several vasculitides.",

author = "Lodge, {Katharine M.} and Tyler Morrison and Cowburn, {Andrew S.} and Walmlsey, {Sarah R.} and Chilvers, {Edwin R.}",

year = "2020",

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doi = "10.1016/B978-0-12-801238-3.11695-2",

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T1 - LEUKOCYTES | Neutrophils

AU - Lodge, Katharine M.

AU - Morrison, Tyler

AU - Cowburn, Andrew S.

AU - Walmlsey, Sarah R.

AU - Chilvers, Edwin R.

PY - 2020/5/28

Y1 - 2020/5/28

N2 - The neutrophil is a phagocytic leukocyte, the most abundant in the human body and the most short-lived of all myeloid cells. This polymorphonuclear cell is packed with granules containing potent antimicrobial compounds and is absolutely essential for day-to-day successful defense against bacterial and fungal infections. Its recruitment and activation are carefully regulated, and control of its life span coupled with mechanisms allowing for a noninflammatory death pathway (apoptosis) reduce risks of tissue damage and disease arising from unwanted neutrophil activation. Given their destructive potential, and despite intensive regulation of their function, it is unsurprising that neutrophilic inflammatory diseases are prevalent; these include asthma, chronic obstructive pulmonary disease, the acute respiratory distress syndrome, and several vasculitides.

AB - The neutrophil is a phagocytic leukocyte, the most abundant in the human body and the most short-lived of all myeloid cells. This polymorphonuclear cell is packed with granules containing potent antimicrobial compounds and is absolutely essential for day-to-day successful defense against bacterial and fungal infections. Its recruitment and activation are carefully regulated, and control of its life span coupled with mechanisms allowing for a noninflammatory death pathway (apoptosis) reduce risks of tissue damage and disease arising from unwanted neutrophil activation. Given their destructive potential, and despite intensive regulation of their function, it is unsurprising that neutrophilic inflammatory diseases are prevalent; these include asthma, chronic obstructive pulmonary disease, the acute respiratory distress syndrome, and several vasculitides.

U2 - 10.1016/B978-0-12-801238-3.11695-2

DO - 10.1016/B978-0-12-801238-3.11695-2

M3 - Chapter

BT - Reference Module in Biomedical Sciences

PB - Elsevier

ER -

LEUKOCYTES | Neutrophils

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