Levels of hepatitis C virus in blood donors infected with different viral genotypes

International HCV Collaborative Study Group; D B  Smith; F  Davidson; P L  Yap; H  Brown; J  Kolberg; J  Detmer; M  Urdea; P  Simmonds

doi:10.1093/infdis/173.3.727

Levels of hepatitis C virus in blood donors infected with different viral genotypes

International HCV Collaborative Study Group, D B Smith, F Davidson, P L Yap, H Brown, J Kolberg, J Detmer, M Urdea, P Simmonds

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

The level of hepatitis C virus (HCV) in the serum of 337 blood donors infected with different viral genotypes was investigated by branched DNA assay, Viral genotype was deduced by restriction analysis of the virus 5'-noncoding region, Samples included genotypes la, Ib, 2a, 2b, 3, 4, 5, and 6. Multivariate analysis revealed that the ranges of HCV levels were similar for all viral genotypes and subtypes (P = .18), with the possible exception of genotype 4. Virus levels were significantly lower in female than male subjects (P < .001) but did not correlate with donor age (P = .06) or country of origin (P = .07), Alanine aminotransferase level was not correlated with virus level or genotype or with donor age, sex, or country. These results indicate a similar replicative capacity in vivo for different HCV genotypes and clarify the influence of host and virus factors on disease severity and responsiveness to interferon treatment.

Original language	English
Pages (from-to)	727-730
Number of pages	4
Journal	The Journal of Infectious Diseases
Volume	173
Issue number	3
DOIs	https://doi.org/10.1093/infdis/173.3.727
Publication status	Published - Mar 1996

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@article{47f269111cc14f438c54e887db1d47a4,

title = "Levels of hepatitis C virus in blood donors infected with different viral genotypes",

abstract = "The level of hepatitis C virus (HCV) in the serum of 337 blood donors infected with different viral genotypes was investigated by branched DNA assay, Viral genotype was deduced by restriction analysis of the virus 5'-noncoding region, Samples included genotypes la, Ib, 2a, 2b, 3, 4, 5, and 6. Multivariate analysis revealed that the ranges of HCV levels were similar for all viral genotypes and subtypes (P = .18), with the possible exception of genotype 4. Virus levels were significantly lower in female than male subjects (P < .001) but did not correlate with donor age (P = .06) or country of origin (P = .07), Alanine aminotransferase level was not correlated with virus level or genotype or with donor age, sex, or country. These results indicate a similar replicative capacity in vivo for different HCV genotypes and clarify the influence of host and virus factors on disease severity and responsiveness to interferon treatment.",

author = "{International HCV Collaborative Study Group} and Smith, {D B} and F Davidson and Yap, {P L} and H Brown and J Kolberg and J Detmer and M Urdea and P Simmonds and J Mellor and J Neville and L Prescott and Dow, {B C} and Follett, {E A C} and T Skuldamrongpanich and S Tanprasert and C Nuchaprayoon and Lin, {C K} and Kew, {M C} and R Crookes and Conradie, {J D} and M Lin and C Seed and deOlim, {G A B} and Martins, {I A} and Medgyesi, {G A} and T Krusius and Saeed, {A A} and D Teo and Lee, {S H}",

year = "1996",

month = mar,

doi = "10.1093/infdis/173.3.727",

language = "English",

volume = "173",

pages = "727--730",

journal = "The Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "3",

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TY - JOUR

T1 - Levels of hepatitis C virus in blood donors infected with different viral genotypes

AU - International HCV Collaborative Study Group

AU - Smith, D B

AU - Davidson, F

AU - Yap, P L

AU - Brown, H

AU - Kolberg, J

AU - Detmer, J

AU - Urdea, M

AU - Simmonds, P

AU - Mellor, J

AU - Neville, J

AU - Prescott, L

AU - Dow, B C

AU - Follett, E A C

AU - Skuldamrongpanich, T

AU - Tanprasert, S

AU - Nuchaprayoon, C

AU - Lin, C K

AU - Kew, M C

AU - Crookes, R

AU - Conradie, J D

AU - Lin, M

AU - Seed, C

AU - deOlim, G A B

AU - Martins, I A

AU - Medgyesi, G A

AU - Krusius, T

AU - Saeed, A A

AU - Teo, D

AU - Lee, S H

PY - 1996/3

Y1 - 1996/3

N2 - The level of hepatitis C virus (HCV) in the serum of 337 blood donors infected with different viral genotypes was investigated by branched DNA assay, Viral genotype was deduced by restriction analysis of the virus 5'-noncoding region, Samples included genotypes la, Ib, 2a, 2b, 3, 4, 5, and 6. Multivariate analysis revealed that the ranges of HCV levels were similar for all viral genotypes and subtypes (P = .18), with the possible exception of genotype 4. Virus levels were significantly lower in female than male subjects (P < .001) but did not correlate with donor age (P = .06) or country of origin (P = .07), Alanine aminotransferase level was not correlated with virus level or genotype or with donor age, sex, or country. These results indicate a similar replicative capacity in vivo for different HCV genotypes and clarify the influence of host and virus factors on disease severity and responsiveness to interferon treatment.

AB - The level of hepatitis C virus (HCV) in the serum of 337 blood donors infected with different viral genotypes was investigated by branched DNA assay, Viral genotype was deduced by restriction analysis of the virus 5'-noncoding region, Samples included genotypes la, Ib, 2a, 2b, 3, 4, 5, and 6. Multivariate analysis revealed that the ranges of HCV levels were similar for all viral genotypes and subtypes (P = .18), with the possible exception of genotype 4. Virus levels were significantly lower in female than male subjects (P < .001) but did not correlate with donor age (P = .06) or country of origin (P = .07), Alanine aminotransferase level was not correlated with virus level or genotype or with donor age, sex, or country. These results indicate a similar replicative capacity in vivo for different HCV genotypes and clarify the influence of host and virus factors on disease severity and responsiveness to interferon treatment.

U2 - 10.1093/infdis/173.3.727

DO - 10.1093/infdis/173.3.727

M3 - Article

SN - 0022-1899

VL - 173

SP - 727

EP - 730

JO - The Journal of Infectious Diseases

JF - The Journal of Infectious Diseases

IS - 3

ER -

Levels of hepatitis C virus in blood donors infected with different viral genotypes

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