Lexis and grammar of mitochondrial RNA processing in Trypanosomes

Inna Aphasizheva*, Juan Alfonzo, Jason Carnes, Igor Cestari, Jorge Cruz-Reyes, H. Ulrich Göringer, Stephen Hajduk, Julius Lukeš, Susan Madison-Antenucci, Dmitri A. Maslov, Suzanne M. McDermott, Torsten Ochsenreiter, Laurie K. Read, Reza Salavati, Achim Schnaufer, André Schneider, Larry Simpson, Kenneth Stuart, Vyacheslav Yurchenko, Z. Hong ZhouAlena Zíková, Liye Zhang, Sara Zimmer, Ruslan Aphasizhev

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast nucleoid containing mitochondrial DNAs of two kinds: maxicircles encoding ribosomal RNAs (rRNAs) and proteins and minicircles bearing guide RNAs (gRNAs) for mRNA editing. All RNAs are produced by a phage-type RNA polymerase as 3′ extended precursors, which undergo exonucleolytic trimming. Most pre-mRNAs proceed through 3′ adenylation, uridine insertion/deletion editing, and 3′ A/U-tailing. The rRNAs and gRNAs are 3′ uridylated. Historically, RNA editing has attracted major research effort, and recently essential pre- and postediting processing events have been discovered. Here, we classify the key players that transform primary transcripts into mature molecules and regulate their function and turnover.

Original languageEnglish
Pages (from-to)337-355
Number of pages19
JournalTrends in Parasitology
Volume36
Issue number4
Early online date27 Feb 2020
DOIs
Publication statusPublished - 1 Apr 2020

Keywords

  • kinetoplast
  • mitochondria
  • polyadenylation
  • RNA decay
  • RNA editing
  • Trypanosoma

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