Ligand-assisted nickel-catalysed sp(3)-sp(3) homocoupling of unactivated alkyl bromides and its application to the active template synthesis of rotaxanes

Stephen M. Goldup, David A. Leigh, Roy T. McBurney, Paul R. McGonigal, Andrew Plant

Research output: Contribution to journalArticlepeer-review

Abstract

An efficient, mild and operationally simple Ni-catalysed sp(3)-carbon-to-sp(3)-carbon homocoupling of unactivated alkyl bromides has been developed and utilised in the active metal template synthesis of an alkyl chain axle [2]rotaxane. The key to the transformation is the use of tridentate nitrogen-donor-atom (terpy or pybox derived) ligands which inhibit competing beta-hydride elimination of alkyl-Ni intermediates.

Original languageEnglish
Pages (from-to)383-386
Number of pages4
JournalChemical Science
Volume1
Issue number3
DOIs
Publication statusPublished - 1 Sep 2010

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