Lineage divergence of activity-driven transcription and evolution of cognitive ability

Giles E Hardingham, Priit Pruunsild, Michael E Greenberg, Hilmar Bading

Research output: Contribution to journalArticlepeer-review

Abstract

Excitation-transcription coupling shapes network formation during brain development and controls neuronal survival, synaptic function and cognitive skills in the adult. New studies have uncovered differences in the transcriptional responses to synaptic activity between humans and mice. These differences are caused both by the emergence of lineage-specific activity-regulated genes and by the acquisition of signal-responsive DNA elements in gene regulatory regions that determine whether a gene can be transcriptionally induced by synaptic activity or alter the extent of its inducibility. Such evolutionary divergence may have contributed to lineage-related advancements in cognitive abilities.

Original languageEnglish
Pages (from-to)9-15
Number of pages7
JournalNature Reviews Neuroscience
Volume19
Issue number1
Early online date23 Nov 2017
DOIs
Publication statusE-pub ahead of print - 23 Nov 2017

Keywords

  • Animals
  • Cell Lineage
  • Cognition
  • Gene Expression Regulation
  • Humans
  • Mice
  • Species Specificity
  • Synaptic Transmission
  • Transcription, Genetic
  • Transcriptional Activation
  • Journal Article
  • Review

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