Linking innate and acquired immunity: divergent role of CD46 cytoplasmic domains in T cell induced inflammation

Julien C Marie, Anne L Astier, Pierre Rivailler, Chantal Rabourdin-Combe, T Fabian Wild, Branka Horvat

Research output: Contribution to journalArticlepeer-review

Abstract

CD46 is a widely expressed transmembrane protein that was initially identified as binding and inactivating C3b and C4b complement products. We used mice that were transgenic for one of two human CD46 isoforms that differ in their cytoplasmic domains (termed CD46-1 and CD46-2) to analyze the effect of CD46 stimulation on the immune response. We show here that CD46 can regulate inflammatory responses, either by inhibiting (CD46-1) or increasing (CD46-2) the contact hypersensitivity reaction. We found that engagement of CD46-1 or CD46-2 differentially affected CD8(+) T cell cytotoxicity, CD4(+) T cell proliferation, interleukin 2 (IL-2) and IL-10 production as well as tyrosine phosphorylation of Vav in T lymphocytes. These results indicate that CD46 plays a role in regulating the T cell induced inflammatory reaction and in fine-tuning the cellular immune response by bridging innate and acquired immunity.
Original languageEnglish
Pages (from-to)659-66
Number of pages8
JournalNature Immunology
Volume3
Issue number7
DOIs
Publication statusPublished - 2002

Keywords

  • Animals
  • Antigens, CD
  • Antigens, CD46
  • Binding Sites
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Cell Division
  • Cytoplasm
  • Cytotoxicity, Immunologic
  • Dermatitis, Contact
  • Dinitrofluorobenzene
  • Disease Models, Animal
  • Immunity, Active
  • Immunity, Innate
  • Interleukin-10
  • Interleukin-2
  • Membrane Glycoproteins
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Protein Isoforms
  • Signal Transduction

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