Linking T cells to Alzheimer's disease: from neurodegeneration to neurorepair

Karen J Bryson, Marina A Lynch

Research output: Contribution to journalReview articlepeer-review

Abstract

The overly-simplistic view that inflammatory and anti-inflammatory influences in the brain were respectively detrimental and advantageous in Alzheimer's disease (AD) is being challenged by advances in methodologies, and a debate relating to immune surveillance mechanisms in the brain. In contrast with previous findings, increasing interleukin (IL)-4 and IL-10 in brain by a recently-developed adenoviral delivery method, had detrimental effects in an animal model of AD, and the ability to isolate the choroid plexus has opened the debate on the role of this specialized tissue in immune surveillance. Delivery of polarized T cells to animal models of AD by different routes has yielded contrasting results; analysis of these diverse responses is vital to understand the role of T cells in the brain in AD, first reported over 25 years ago.

Original languageEnglish
Pages (from-to)67-73
Number of pages7
JournalCurrent Opinion in Pharmacology
Volume26
Early online date27 Oct 2015
DOIs
Publication statusE-pub ahead of print - 27 Oct 2015

Keywords

  • Adaptive Immunity
  • Alzheimer Disease/immunology
  • Animals
  • Brain/immunology
  • Humans
  • T-Lymphocytes/immunology

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