Lipid and protein maps defining arterial layers in atherosclerotic aorta

Marta Martin-Lorenzo, Benjamin Balluff, Aroa S Maroto, Ricardo J Carreira, Rene J M van Zeijl, Laura Gonzalez-Calero, Fernando de la Cuesta, Maria G Barderas, Luis F Lopez-Almodovar, Luis R Padial, Liam A McDonnell, Fernando Vivanco, Gloria Alvarez-Llamas

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Subclinical atherosclerosis cannot be predicted and novel therapeutic targets are needed. The molecular anatomy of healthy and atherosclerotic tissue is pursued to identify ongoing molecular changes in atherosclerosis development. Mass Spectrometry Imaging (MSI) accounts with the unique advantage of analyzing proteins and metabolites (lipids) while preserving their original localization; thus two dimensional maps can be obtained. Main molecular alterations were investigated in a rabbit model in response to early development of atherosclerosis. Aortic arterial layers (intima and media) and calcified regions were investigated in detail by MALDI-MSI and proteins and lipids specifically defining those areas of interest were identified. These data further complement main findings previously published in J Proteomics (M. Martin-Lorenzo et al., J. Proteomics. (In press); M. Martin-Lorenzo et al., J. Proteomics 108 (2014) 465-468.) [1,2].

Original languageEnglish
Pages (from-to)328-31
Number of pages4
JournalData in brief
Publication statusPublished - Sept 2015


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