Lipid and protein maps defining arterial layers in atherosclerotic aorta

Marta Martin-Lorenzo; Benjamin Balluff; Aroa S Maroto; Ricardo J Carreira; Rene J M van Zeijl; Laura Gonzalez-Calero; Fernando de la Cuesta; Maria G Barderas; Luis F Lopez-Almodovar; Luis R Padial; Liam A McDonnell; Fernando Vivanco; Gloria Alvarez-Llamas

doi:10.1016/j.dib.2015.06.005

Lipid and protein maps defining arterial layers in atherosclerotic aorta

Marta Martin-Lorenzo, Benjamin Balluff, Aroa S Maroto, Ricardo J Carreira, Rene J M van Zeijl, Laura Gonzalez-Calero, Fernando de la Cuesta, Maria G Barderas, Luis F Lopez-Almodovar, Luis R Padial, Liam A McDonnell, Fernando Vivanco, Gloria Alvarez-Llamas

Research output: Contribution to journal › Article › peer-review

Abstract

Subclinical atherosclerosis cannot be predicted and novel therapeutic targets are needed. The molecular anatomy of healthy and atherosclerotic tissue is pursued to identify ongoing molecular changes in atherosclerosis development. Mass Spectrometry Imaging (MSI) accounts with the unique advantage of analyzing proteins and metabolites (lipids) while preserving their original localization; thus two dimensional maps can be obtained. Main molecular alterations were investigated in a rabbit model in response to early development of atherosclerosis. Aortic arterial layers (intima and media) and calcified regions were investigated in detail by MALDI-MSI and proteins and lipids specifically defining those areas of interest were identified. These data further complement main findings previously published in J Proteomics (M. Martin-Lorenzo et al., J. Proteomics. (In press); M. Martin-Lorenzo et al., J. Proteomics 108 (2014) 465-468.) [1,2].

Original language	English
Pages (from-to)	328-31
Number of pages	4
Journal	Data in brief
Volume	4
DOIs	https://doi.org/10.1016/j.dib.2015.06.005
Publication status	Published - Sep 2015

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Martin-Lorenzo, M., Balluff, B., Maroto, A. S., Carreira, R. J., van Zeijl, R. J. M., Gonzalez-Calero, L., de la Cuesta, F., Barderas, M. G., Lopez-Almodovar, L. F., Padial, L. R., McDonnell, L. A., Vivanco, F., & Alvarez-Llamas, G. (2015). Lipid and protein maps defining arterial layers in atherosclerotic aorta. Data in brief, 4, 328-31. https://doi.org/10.1016/j.dib.2015.06.005

@article{4b258e105bc14e19829cfc3061194015,

title = "Lipid and protein maps defining arterial layers in atherosclerotic aorta",

abstract = "Subclinical atherosclerosis cannot be predicted and novel therapeutic targets are needed. The molecular anatomy of healthy and atherosclerotic tissue is pursued to identify ongoing molecular changes in atherosclerosis development. Mass Spectrometry Imaging (MSI) accounts with the unique advantage of analyzing proteins and metabolites (lipids) while preserving their original localization; thus two dimensional maps can be obtained. Main molecular alterations were investigated in a rabbit model in response to early development of atherosclerosis. Aortic arterial layers (intima and media) and calcified regions were investigated in detail by MALDI-MSI and proteins and lipids specifically defining those areas of interest were identified. These data further complement main findings previously published in J Proteomics (M. Martin-Lorenzo et al., J. Proteomics. (In press); M. Martin-Lorenzo et al., J. Proteomics 108 (2014) 465-468.) [1,2].",

author = "Marta Martin-Lorenzo and Benjamin Balluff and Maroto, {Aroa S} and Carreira, {Ricardo J} and {van Zeijl}, {Rene J M} and Laura Gonzalez-Calero and {de la Cuesta}, Fernando and Barderas, {Maria G} and Lopez-Almodovar, {Luis F} and Padial, {Luis R} and McDonnell, {Liam A} and Fernando Vivanco and Gloria Alvarez-Llamas",

year = "2015",

month = sep,

doi = "10.1016/j.dib.2015.06.005",

language = "English",

volume = "4",

pages = "328--31",

journal = "Data in brief",

issn = "2352-3409",

publisher = "Elsevier BV",

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T1 - Lipid and protein maps defining arterial layers in atherosclerotic aorta

AU - Martin-Lorenzo, Marta

AU - Balluff, Benjamin

AU - Maroto, Aroa S

AU - Carreira, Ricardo J

AU - van Zeijl, Rene J M

AU - Gonzalez-Calero, Laura

AU - de la Cuesta, Fernando

AU - Barderas, Maria G

AU - Lopez-Almodovar, Luis F

AU - Padial, Luis R

AU - McDonnell, Liam A

AU - Vivanco, Fernando

AU - Alvarez-Llamas, Gloria

PY - 2015/9

Y1 - 2015/9

N2 - Subclinical atherosclerosis cannot be predicted and novel therapeutic targets are needed. The molecular anatomy of healthy and atherosclerotic tissue is pursued to identify ongoing molecular changes in atherosclerosis development. Mass Spectrometry Imaging (MSI) accounts with the unique advantage of analyzing proteins and metabolites (lipids) while preserving their original localization; thus two dimensional maps can be obtained. Main molecular alterations were investigated in a rabbit model in response to early development of atherosclerosis. Aortic arterial layers (intima and media) and calcified regions were investigated in detail by MALDI-MSI and proteins and lipids specifically defining those areas of interest were identified. These data further complement main findings previously published in J Proteomics (M. Martin-Lorenzo et al., J. Proteomics. (In press); M. Martin-Lorenzo et al., J. Proteomics 108 (2014) 465-468.) [1,2].

AB - Subclinical atherosclerosis cannot be predicted and novel therapeutic targets are needed. The molecular anatomy of healthy and atherosclerotic tissue is pursued to identify ongoing molecular changes in atherosclerosis development. Mass Spectrometry Imaging (MSI) accounts with the unique advantage of analyzing proteins and metabolites (lipids) while preserving their original localization; thus two dimensional maps can be obtained. Main molecular alterations were investigated in a rabbit model in response to early development of atherosclerosis. Aortic arterial layers (intima and media) and calcified regions were investigated in detail by MALDI-MSI and proteins and lipids specifically defining those areas of interest were identified. These data further complement main findings previously published in J Proteomics (M. Martin-Lorenzo et al., J. Proteomics. (In press); M. Martin-Lorenzo et al., J. Proteomics 108 (2014) 465-468.) [1,2].

U2 - 10.1016/j.dib.2015.06.005

DO - 10.1016/j.dib.2015.06.005

M3 - Article

C2 - 26217810

VL - 4

SP - 328

EP - 331

JO - Data in brief

JF - Data in brief

SN - 2352-3409

ER -

Lipid and protein maps defining arterial layers in atherosclerotic aorta

Abstract

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