Lipoprotein (a), metabolic syndrome and coronary calcium score in a large occupational cohort

K. -C. Sung*, S. H. Wild, C. D. Byrne

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background and aims: Whether lipoprotein (a) [Lp(a)] concentration is associated with metabolic syndrome (MetS) and pre-clinical atherosclerosis in different ethnic groups is uncertain. The association between Lp(a), MetS and a measure of pre-clinical atherosclerosis was studied in a large Asian cohort.

Methods and results: Data were analyzed from a South Korean occupational cohort who underwent a cardiac computed tomography (CT) estimation of CAC score and measurements of cardiovascular risk factors (n = 14,583 people). The key exposure was an Lp(a) concentration in the top quartile (>38.64 mg/dL)) with a CAC score >0 as the outcome variable and measure of pre-clinical atherosclerosis. Logistic regression was used to describe the associations. 1462 participants had a CAC score >0. In the lowest Lp(a) quartile (38.64 mg/dL (p <0.001). MetS, and component features, were inversely related to Lp(a) concentration (all p <0.0001). In the highest Lp(a) quartile group, there was an association between Lp(a) and CAC score >0 in men (OR 1.21[1.05, 1.40], p = 0.008), and women (OR 1.62[1.03, 2.55], p = 0.038), after adjustment for age, sex, lipid lowering therapy, and multiple cardiovascular risk factors. There was no evidence of an interaction between highest quartile Lp(a) and either high LDLc (>147 mg/dL) (p = 0.99), or MetS (p = 0.84) on the association with CAC score >0.

Conclusion: Lp(a) levels are inversely related to MetS and its components. There was a robust association between Lp(a) concentration >38.6 mg/dL and marker of early atherosclerosis in both men and women, regardless of LDLc, level MetS or other cardiovascular risk factors. (C) 2013 Elsevier B. V. All rights reserved.

Original languageEnglish
Pages (from-to)1239-1246
Number of pages8
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume23
Issue number12
DOIs
Publication statusPublished - 19 Jun 2013

Keywords

  • Lp(a)
  • Coronary artery calcium (CAC) score
  • Atherosclerosis
  • Cardio-metabolic risk factors
  • Cardiovascular disease (CVD)
  • Metabolic syndrome (MetS)
  • HEART-DISEASE
  • HUMAN APOLIPOPROTEIN(A)
  • CARDIOVASCULAR-DISEASE
  • COMPUTED-TOMOGRAPHY
  • GENETIC-VARIANTS
  • RISK
  • PATHOGENICITY
  • PLASMINOGEN
  • MORTALITY

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