Abstract / Description of output
Non-cancerous immune cells can significantly contribute to tumour progression and metastases. Neutrophils associated with tumours can both promote and inhibit tumour progression, but less is known about how non-associated immune cells contribute to cancer biology. In a recent issue of the Journal of Pathology, He and colleagues use non-invasive, high-resolution imaging of the whole living animal to provide a compelling glimpse at how physiological migration of neutrophils can prepare a metastatic niche and how their activities can be altered by the unintended consequences of targeted therapeutics.
Original language | English |
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Pages (from-to) | 381-4 |
Number of pages | 4 |
Journal | The Journal of Pathology |
Volume | 227 |
Issue number | 4 |
DOIs | |
Publication status | Published - Aug 2012 |
Keywords / Materials (for Non-textual outputs)
- Animals
- Disease Models, Animal
- Humans
- Neoplasm Metastasis
- Neutrophils
- Receptors, Vascular Endothelial Growth Factor
- Xenograft Model Antitumor Assays
- Zebrafish