Live imaging in zebrafish reveals neu(trophil) insight into the metastatic niche

Research output: Contribution to journalArticlepeer-review

Abstract

Non-cancerous immune cells can significantly contribute to tumour progression and metastases. Neutrophils associated with tumours can both promote and inhibit tumour progression, but less is known about how non-associated immune cells contribute to cancer biology. In a recent issue of the Journal of Pathology, He and colleagues use non-invasive, high-resolution imaging of the whole living animal to provide a compelling glimpse at how physiological migration of neutrophils can prepare a metastatic niche and how their activities can be altered by the unintended consequences of targeted therapeutics.
Original languageEnglish
Pages (from-to)381-4
Number of pages4
JournalThe Journal of Pathology
Volume227
Issue number4
DOIs
Publication statusPublished - Aug 2012

Keywords

  • Animals
  • Disease Models, Animal
  • Humans
  • Neoplasm Metastasis
  • Neutrophils
  • Receptors, Vascular Endothelial Growth Factor
  • Xenograft Model Antitumor Assays
  • Zebrafish

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