Live lambs born from zona-pellucida denuded embryos

William A Ritchie, Jane E Taylor, John O Gardner, Ian Wilmut, Ailsa Carlisle, Claire Neil, Tim King, C Bruce A Whitelaw

Research output: Contribution to journalArticlepeer-review


Progress with techniques using zona-pellucida denuded embryos has resulted in the birth of live cattle, pigs, and mice. The application of zona-free methods in sheep has been restricted to in vitro studies. In this report, we demonstrate that live lambs can be produced from zona-free IVF embryos. We are pursuing this method as a prerequisite to developing viral vector co-culture delivery strategies.
Original languageEnglish
Pages (from-to)178-82
Number of pages5
JournalCloning and Stem Cells
Issue number3
Publication statusPublished - 2005


  • Animals
  • Animals, Newborn
  • Embryo Transfer
  • Embryo, Mammalian
  • Female
  • Fertilization in Vitro
  • Pregnancy
  • Sheep
  • Zona Pellucida


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