Liver biopsy interpretation for causes of late liver allograft dysfunction

Banff Working Group, Anthony J Demetris, Oyedele Adeyi, Christopher Bellamy, Andrew Clouston, Frederic Charlotte, Albert Czaja, Paulo Fontes, Ierachmiel Daskal, Magda S El-Monayeri, John Fung, Bruno Gridelli, Hironori Haga, Maria Guido, John Hart, Eva Honsova, Stefan Hubscher, Tomoo Itoh, Nirag Jhala, Patricia JungmannUrmila Khettry, Charles Lassman, Saverio Ligato, John G Lunz, Amadeo Marcos, Marta Ida Minervini, Johan Mölne, Mike Nalesnik, Imad Nasser, Desley Neil, Erin Ochoa, Parmjeet Randhawa, Orit Pappo, Phil Ruiz, Finn P Reinholt, Aurelio Sonzogni, Mylène Sebagh, Marco Spada, Athanassios C Tsamandas, Annika Wernerson, Tong Wu, Funda Yilmaz

Research output: Contribution to journalArticlepeer-review


Evaluation of needle biopsies and extensive clinicopathological correlation play an important role in the determination of liver allograft dysfunction occurring more than 1 year after transplantation. Interpretation of these biopsies can be quite difficult because of the high incidence of recurrent diseases that show histopathological, clinical, and serological features that overlap with each other and with rejection. Also, more than one insult can contribute to allograft injury. In an attempt to enable centers to compare and pool results, improve therapy, and better understand pathophysiological disease mechanisms, the Banff Working Group on Liver Allograft Pathology herein proposes a set of consensus criteria for the most common and problematic causes of late liver allograft dysfunction, including late-onset acute and chronic rejection, recurrent and new-onset viral and autoimmune hepatitis, biliary strictures, and recurrent primary biliary cirrhosis and primary sclerosing cholangitis. A discussion of differential diagnosis is also presented.
Original languageEnglish
Pages (from-to)489-501
Number of pages13
Issue number2
Publication statusPublished - Aug 2006


  • Biopsy, Needle
  • Diagnosis, Differential
  • Follow-Up Studies
  • Graft Rejection
  • Humans
  • Liver
  • Liver Transplantation
  • Time Factors
  • Transplantation, Homologous


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