Liver fibrosis and repair: immune regulation of wound healing in a solid organ

Antonella Pellicoro; Prakash Ramachandran; John P. Iredale; Jonathan A. Fallowfield

doi:10.1038/nri3623

Liver fibrosis and repair: immune regulation of wound healing in a solid organ

Antonella Pellicoro, Prakash Ramachandran, John P. Iredale, Jonathan A. Fallowfield^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Fibrosis is a highly conserved and co-ordinated protective response to tissue injury. The interaction of multiple pathways, molecules and systems determines whether fibrosis is self-limiting and homeostatic, or whether it is uncontrolled and excessive. Immune cells have been identified as key players in this fibrotic cascade, with the capacity to exert either injury-inducing or repair-promoting effects. A multi-organ approach was recently suggested to identify the core and regulatory pathways in fibrosis, with the aim of integrating the wealth of information emerging from basic fibrosis research. In this Review, we focus on recent advances in liver fibrosis research as a paradigm for wound healing in solid organs and the role of the immune system in regulating and balancing this response.

Original language	English
Pages (from-to)	181-194
Number of pages	14
Journal	Nature Reviews Immunology
Volume	14
Issue number	3
DOIs	https://doi.org/10.1038/nri3623
Publication status	Published - Mar 2014

Keywords / Materials (for Non-textual outputs)

HEPATIC STELLATE CELLS
ANTIGEN-PRESENTING CELLS
T-CELLS
TISSUE INHIBITOR
BILIARY FIBROSIS
KUPFFER CELLS
RAT-LIVER
MYOFIBROBLAST TRANSDIFFERENTIATION
SCHISTOSOME INFECTION
PULMONARY-FIBROSIS

Access to Document

10.1038/nri3623

http://www.nature.com/nri/journal/v14/n3/full/nri3623.html

PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY
Iredale, J.
MRC
1/09/12 → 31/08/16
Project: Research
Defining the macrophage regulatory T cell axis that promotes fibrosis resolution in the liver
Iredale, J., Anderton, S. & Forbes, S.
MRC
1/06/12 → 28/02/18
Project: Research

Cite this

@article{2e2413e33dad427a84f470378ca34abb,

title = "Liver fibrosis and repair: immune regulation of wound healing in a solid organ",

abstract = "Fibrosis is a highly conserved and co-ordinated protective response to tissue injury. The interaction of multiple pathways, molecules and systems determines whether fibrosis is self-limiting and homeostatic, or whether it is uncontrolled and excessive. Immune cells have been identified as key players in this fibrotic cascade, with the capacity to exert either injury-inducing or repair-promoting effects. A multi-organ approach was recently suggested to identify the core and regulatory pathways in fibrosis, with the aim of integrating the wealth of information emerging from basic fibrosis research. In this Review, we focus on recent advances in liver fibrosis research as a paradigm for wound healing in solid organs and the role of the immune system in regulating and balancing this response.",

keywords = "HEPATIC STELLATE CELLS, ANTIGEN-PRESENTING CELLS, T-CELLS, TISSUE INHIBITOR, BILIARY FIBROSIS, KUPFFER CELLS, RAT-LIVER, MYOFIBROBLAST TRANSDIFFERENTIATION, SCHISTOSOME INFECTION, PULMONARY-FIBROSIS",

author = "Antonella Pellicoro and Prakash Ramachandran and Iredale, {John P.} and Fallowfield, {Jonathan A.}",

year = "2014",

month = mar,

doi = "10.1038/nri3623",

language = "English",

volume = "14",

pages = "181--194",

journal = "Nature Reviews Immunology",

issn = "1474-1733",

publisher = "Nature Publishing Group",

number = "3",

}

TY - JOUR

T1 - Liver fibrosis and repair: immune regulation of wound healing in a solid organ

AU - Pellicoro, Antonella

AU - Ramachandran, Prakash

AU - Iredale, John P.

AU - Fallowfield, Jonathan A.

PY - 2014/3

Y1 - 2014/3

N2 - Fibrosis is a highly conserved and co-ordinated protective response to tissue injury. The interaction of multiple pathways, molecules and systems determines whether fibrosis is self-limiting and homeostatic, or whether it is uncontrolled and excessive. Immune cells have been identified as key players in this fibrotic cascade, with the capacity to exert either injury-inducing or repair-promoting effects. A multi-organ approach was recently suggested to identify the core and regulatory pathways in fibrosis, with the aim of integrating the wealth of information emerging from basic fibrosis research. In this Review, we focus on recent advances in liver fibrosis research as a paradigm for wound healing in solid organs and the role of the immune system in regulating and balancing this response.

AB - Fibrosis is a highly conserved and co-ordinated protective response to tissue injury. The interaction of multiple pathways, molecules and systems determines whether fibrosis is self-limiting and homeostatic, or whether it is uncontrolled and excessive. Immune cells have been identified as key players in this fibrotic cascade, with the capacity to exert either injury-inducing or repair-promoting effects. A multi-organ approach was recently suggested to identify the core and regulatory pathways in fibrosis, with the aim of integrating the wealth of information emerging from basic fibrosis research. In this Review, we focus on recent advances in liver fibrosis research as a paradigm for wound healing in solid organs and the role of the immune system in regulating and balancing this response.

KW - HEPATIC STELLATE CELLS

KW - ANTIGEN-PRESENTING CELLS

KW - T-CELLS

KW - TISSUE INHIBITOR

KW - BILIARY FIBROSIS

KW - KUPFFER CELLS

KW - RAT-LIVER

KW - MYOFIBROBLAST TRANSDIFFERENTIATION

KW - SCHISTOSOME INFECTION

KW - PULMONARY-FIBROSIS

U2 - 10.1038/nri3623

DO - 10.1038/nri3623

M3 - Article

SN - 1474-1733

VL - 14

SP - 181

EP - 194

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

IS - 3

ER -

Liver fibrosis and repair: immune regulation of wound healing in a solid organ

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

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Projects

PhD STUDENT - JOANNE SIMPSON - Supervisor MOHINI GRAY

Defining the macrophage regulatory T cell axis that promotes fibrosis resolution in the liver

Cite this