Liver iron overloading in captive muriquis (Brachyteles spp.)

Stéfanie V Santos; Ricardo De F Strefezzi; Alcides Pissinatti; José L Catão-Dias

doi:10.1111/j.1600-0684.2010.00459.x

Liver iron overloading in captive muriquis (Brachyteles spp.)

Stéfanie V Santos, Ricardo De F Strefezzi, Alcides Pissinatti, José L Catão-Dias

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Iron accumulation was investigated qualitatively and quantitatively in the liver of 15 captive Brachyteles spp.

METHODS: Hepatic hemosiderosis index (HHI) was determined as the area percentage of the liver parenchyma occupied by hemosiderin and ferritin deposits, through computerized histomorphometric analysis of Prussian blue-stained histologic sections.

RESULTS: All studied animals presented liver hemosiderosis, and HHI ranged from 0.2% to 41.7%. There were no significant differences in HHI between muriqui species or genders, and no correlations were detected among HHI and age, time in captivity or body mass. Iron deposits were accompanied by other hepatic disorders.

CONCLUSIONS: This is the first study addressing the occurrence and consequences of iron overloading in the liver of muriquis. We propose that hemosiderosis may act as a contribute factor for the development of hepatic injuries. Further studies are advised to clarify the role of diet in the pathogenesis of hemosiderosis in these atelids.

Original language	English
Pages (from-to)	129-34
Number of pages	6
Journal	Journal of medical primatology
Volume	40
Issue number	2
DOIs	https://doi.org/10.1111/j.1600-0684.2010.00459.x
Publication status	Published - Apr 2011

Keywords / Materials (for Non-textual outputs)

Animals
Atelinae
Hemosiderosis/epidemiology
Liver/pathology
Monkey Diseases/epidemiology

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10.1111/j.1600-0684.2010.00459.x

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title = "Liver iron overloading in captive muriquis (Brachyteles spp.)",

abstract = "BACKGROUND: Iron accumulation was investigated qualitatively and quantitatively in the liver of 15 captive Brachyteles spp.METHODS: Hepatic hemosiderosis index (HHI) was determined as the area percentage of the liver parenchyma occupied by hemosiderin and ferritin deposits, through computerized histomorphometric analysis of Prussian blue-stained histologic sections.RESULTS: All studied animals presented liver hemosiderosis, and HHI ranged from 0.2\% to 41.7\%. There were no significant differences in HHI between muriqui species or genders, and no correlations were detected among HHI and age, time in captivity or body mass. Iron deposits were accompanied by other hepatic disorders.CONCLUSIONS: This is the first study addressing the occurrence and consequences of iron overloading in the liver of muriquis. We propose that hemosiderosis may act as a contribute factor for the development of hepatic injuries. Further studies are advised to clarify the role of diet in the pathogenesis of hemosiderosis in these atelids.",

keywords = "Animals, Atelinae, Hemosiderosis/epidemiology, Liver/pathology, Monkey Diseases/epidemiology",

author = "Santos, \{St{\'e}fanie V\} and Strefezzi, \{Ricardo De F\} and Alcides Pissinatti and Cat{\~a}o-Dias, \{Jos{\'e} L\}",

note = "{\textcopyright} 2010 John Wiley \& Sons A/S.",

year = "2011",

month = apr,

doi = "10.1111/j.1600-0684.2010.00459.x",

language = "English",

volume = "40",

pages = "129--34",

journal = "Journal of medical primatology",

issn = "0047-2565",

publisher = "Blackwell Munksgaard",

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TY - JOUR

T1 - Liver iron overloading in captive muriquis (Brachyteles spp.)

AU - Santos, Stéfanie V

AU - Strefezzi, Ricardo De F

AU - Pissinatti, Alcides

AU - Catão-Dias, José L

PY - 2011/4

Y1 - 2011/4

N2 - BACKGROUND: Iron accumulation was investigated qualitatively and quantitatively in the liver of 15 captive Brachyteles spp.METHODS: Hepatic hemosiderosis index (HHI) was determined as the area percentage of the liver parenchyma occupied by hemosiderin and ferritin deposits, through computerized histomorphometric analysis of Prussian blue-stained histologic sections.RESULTS: All studied animals presented liver hemosiderosis, and HHI ranged from 0.2% to 41.7%. There were no significant differences in HHI between muriqui species or genders, and no correlations were detected among HHI and age, time in captivity or body mass. Iron deposits were accompanied by other hepatic disorders.CONCLUSIONS: This is the first study addressing the occurrence and consequences of iron overloading in the liver of muriquis. We propose that hemosiderosis may act as a contribute factor for the development of hepatic injuries. Further studies are advised to clarify the role of diet in the pathogenesis of hemosiderosis in these atelids.

AB - BACKGROUND: Iron accumulation was investigated qualitatively and quantitatively in the liver of 15 captive Brachyteles spp.METHODS: Hepatic hemosiderosis index (HHI) was determined as the area percentage of the liver parenchyma occupied by hemosiderin and ferritin deposits, through computerized histomorphometric analysis of Prussian blue-stained histologic sections.RESULTS: All studied animals presented liver hemosiderosis, and HHI ranged from 0.2% to 41.7%. There were no significant differences in HHI between muriqui species or genders, and no correlations were detected among HHI and age, time in captivity or body mass. Iron deposits were accompanied by other hepatic disorders.CONCLUSIONS: This is the first study addressing the occurrence and consequences of iron overloading in the liver of muriquis. We propose that hemosiderosis may act as a contribute factor for the development of hepatic injuries. Further studies are advised to clarify the role of diet in the pathogenesis of hemosiderosis in these atelids.

KW - Animals

KW - Atelinae

KW - Hemosiderosis/epidemiology

KW - Liver/pathology

KW - Monkey Diseases/epidemiology

U2 - 10.1111/j.1600-0684.2010.00459.x

DO - 10.1111/j.1600-0684.2010.00459.x

M3 - Article

C2 - 21087287

SN - 0047-2565

VL - 40

SP - 129

EP - 134

JO - Journal of medical primatology

JF - Journal of medical primatology

IS - 2

ER -

Liver iron overloading in captive muriquis (Brachyteles spp.)

Abstract

Keywords / Materials (for Non-textual outputs)

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