Liver zonation, revisited

Research output: Contribution to journalReview articlepeer-review


The concept of hepatocyte functional zonation is well established, with differences in metabolism and xenobiotic processing determined by multiple factors including oxygen and nutrient levels across the hepatic lobule. However, recent advances in single-cell genomics technologies, including single-cell and nuclei RNA sequencing, and the rapidly evolving fields of spatial transcriptomic and proteomic profiling have greatly increased our understanding of liver zonation. Here we discuss how these transformative experimental strategies are being leveraged to dissect liver zonation at unprecedented resolution and how this new information should facilitate the emergence of novel precision medicine-based therapies for patients with liver disease.
Original languageEnglish
Article number2022 :00:1-12
Pages (from-to)1219-1230
Number of pages12
Issue number4
Early online date17 Feb 2022
Publication statusPublished - Oct 2022


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