LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest

Jennifer P Morton, Nigel B Jamieson, Saadia A Karim, Dimitris Athineos, Rachel A Ridgway, Colin Nixon, Colin J McKay, Ross Carter, Valerie G Brunton, Margaret C Frame, Alan Ashworth, Karin A Oien, T R Jeffry Evans, Owen J Sansom

Research output: Contribution to journalArticlepeer-review

Abstract

Patients carrying germline mutations of LKB1 have an increased risk of pancreatic cancer; however, it is unclear whether down-regulation of LKB1 is an important event in sporadic pancreatic cancer. In this study, we aimed to investigate the impact of LKB1 down-regulation for pancreatic cancer in mouse and human and to elucidate the mechanism by which Lkb1 deregulation contributes to this disease.
Original languageEnglish
Pages (from-to)586-97, 597.e1-6
JournalGastroenterology
Volume139
Issue number2
DOIs
Publication statusPublished - 2010

Keywords

  • Pancreatic Cancer
  • Kras
  • LKb1
  • p21

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