LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest

Jennifer P Morton; Nigel B Jamieson; Saadia A Karim; Dimitris Athineos; Rachel A Ridgway; Colin Nixon; Colin J McKay; Ross Carter; Valerie G Brunton; Margaret C Frame; Alan Ashworth; Karin A Oien; T R Jeffry Evans; Owen J Sansom

doi:10.1053/j.gastro.2010.04.055

LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest

Jennifer P Morton, Nigel B Jamieson, Saadia A Karim, Dimitris Athineos, Rachel A Ridgway, Colin Nixon, Colin J McKay, Ross Carter, Valerie G Brunton, Margaret C Frame, Alan Ashworth, Karin A Oien, T R Jeffry Evans, Owen J Sansom

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Patients carrying germline mutations of LKB1 have an increased risk of pancreatic cancer; however, it is unclear whether down-regulation of LKB1 is an important event in sporadic pancreatic cancer. In this study, we aimed to investigate the impact of LKB1 down-regulation for pancreatic cancer in mouse and human and to elucidate the mechanism by which Lkb1 deregulation contributes to this disease.

Original language	English
Pages (from-to)	586-97, 597.e1-6
Journal	Gastroenterology
Volume	139
Issue number	2
DOIs	https://doi.org/10.1053/j.gastro.2010.04.055
Publication status	Published - 2010

Keywords / Materials (for Non-textual outputs)

Pancreatic Cancer
Kras
LKb1
p21

Access to Document

10.1053/j.gastro.2010.04.055

Morton et al 2010
Open access article
Final published version, 3.96 MB

Cite this

Morton, J. P., Jamieson, N. B., Karim, S. A., Athineos, D., Ridgway, R. A., Nixon, C., McKay, C. J., Carter, R., Brunton, V. G., Frame, M. C., Ashworth, A., Oien, K. A., Evans, T. R. J., & Sansom, O. J. (2010). LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest. Gastroenterology, 139(2), 586-97, 597.e1-6. https://doi.org/10.1053/j.gastro.2010.04.055

@article{87ef25ad599743f9a86600e876cb5a26,

title = "LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest",

abstract = "Patients carrying germline mutations of LKB1 have an increased risk of pancreatic cancer; however, it is unclear whether down-regulation of LKB1 is an important event in sporadic pancreatic cancer. In this study, we aimed to investigate the impact of LKB1 down-regulation for pancreatic cancer in mouse and human and to elucidate the mechanism by which Lkb1 deregulation contributes to this disease.",

keywords = "Pancreatic Cancer, Kras, LKb1, p21",

author = "Morton, {Jennifer P} and Jamieson, {Nigel B} and Karim, {Saadia A} and Dimitris Athineos and Ridgway, {Rachel A} and Colin Nixon and McKay, {Colin J} and Ross Carter and Brunton, {Valerie G} and Frame, {Margaret C} and Alan Ashworth and Oien, {Karin A} and Evans, {T R Jeffry} and Sansom, {Owen J}",

year = "2010",

doi = "10.1053/j.gastro.2010.04.055",

language = "English",

volume = "139",

pages = "586--97, 597.e1--6",

journal = "Gastroenterology",

issn = "0016-5085",

publisher = "W.B. Saunders Company",

number = "2",

}

Morton, JP, Jamieson, NB, Karim, SA, Athineos, D, Ridgway, RA, Nixon, C, McKay, CJ, Carter, R, Brunton, VG , Frame, MC, Ashworth, A, Oien, KA, Evans, TRJ & Sansom, OJ 2010, 'LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest', Gastroenterology, vol. 139, no. 2, pp. 586-97, 597.e1-6. https://doi.org/10.1053/j.gastro.2010.04.055

TY - JOUR

T1 - LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest

AU - Morton, Jennifer P

AU - Jamieson, Nigel B

AU - Karim, Saadia A

AU - Athineos, Dimitris

AU - Ridgway, Rachel A

AU - Nixon, Colin

AU - McKay, Colin J

AU - Carter, Ross

AU - Brunton, Valerie G

AU - Frame, Margaret C

AU - Ashworth, Alan

AU - Oien, Karin A

AU - Evans, T R Jeffry

AU - Sansom, Owen J

PY - 2010

Y1 - 2010

N2 - Patients carrying germline mutations of LKB1 have an increased risk of pancreatic cancer; however, it is unclear whether down-regulation of LKB1 is an important event in sporadic pancreatic cancer. In this study, we aimed to investigate the impact of LKB1 down-regulation for pancreatic cancer in mouse and human and to elucidate the mechanism by which Lkb1 deregulation contributes to this disease.

AB - Patients carrying germline mutations of LKB1 have an increased risk of pancreatic cancer; however, it is unclear whether down-regulation of LKB1 is an important event in sporadic pancreatic cancer. In this study, we aimed to investigate the impact of LKB1 down-regulation for pancreatic cancer in mouse and human and to elucidate the mechanism by which Lkb1 deregulation contributes to this disease.

KW - Pancreatic Cancer

KW - Kras

KW - LKb1

KW - p21

U2 - 10.1053/j.gastro.2010.04.055

DO - 10.1053/j.gastro.2010.04.055

M3 - Article

C2 - 20452353

SN - 0016-5085

VL - 139

SP - 586-97, 597.e1-6

JO - Gastroenterology

JF - Gastroenterology

IS - 2

ER -

LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

Fingerprint

Cite this