LncRNA/microRNA interactions in the vasculature

Margaret D Ballantyne; Robert A McDonald; Andrew H Baker

doi:10.1002/cpt.355

LncRNA/microRNA interactions in the vasculature

Margaret D Ballantyne, Robert A McDonald, Andrew H Baker

Research output: Contribution to journal › Literature review › peer-review

Abstract / Description of output

MicroRNA (miR) have gained widespread attention for their role in diverse vascular processes including angiogenesis, apoptosis, proliferation and migration. Despite great understanding of microRNA expression and function; knowledge of long non-coding RNA (lncRNA) molecular mechanisms still remains limited. The influence of microRNA on lncRNA function, and the converse, is now beginning to emerge. LncRNA may regulate microRNA function by acting as endogenous sponges to regulate gene expression and microRNA have been shown to bind and regulate lncRNA stability. A detailed understanding of the molecular and cellular effects of lncRNA-microRNA-mediated interactions in vascular pathophysiology could pave the way for new diagnostic markers and therapeutic approaches, but first there is a requirement for a more detailed understanding of the impact of such regulatory networks. This article is protected by copyright. All rights reserved.

Original language	English
Journal	Clinical Pharmacology & Therapeutics
Early online date	31 Mar 2016
DOIs	https://doi.org/10.1002/cpt.355
Publication status	E-pub ahead of print - 31 Mar 2016

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title = "LncRNA/microRNA interactions in the vasculature",

abstract = "MicroRNA (miR) have gained widespread attention for their role in diverse vascular processes including angiogenesis, apoptosis, proliferation and migration. Despite great understanding of microRNA expression and function; knowledge of long non-coding RNA (lncRNA) molecular mechanisms still remains limited. The influence of microRNA on lncRNA function, and the converse, is now beginning to emerge. LncRNA may regulate microRNA function by acting as endogenous sponges to regulate gene expression and microRNA have been shown to bind and regulate lncRNA stability. A detailed understanding of the molecular and cellular effects of lncRNA-microRNA-mediated interactions in vascular pathophysiology could pave the way for new diagnostic markers and therapeutic approaches, but first there is a requirement for a more detailed understanding of the impact of such regulatory networks. This article is protected by copyright. All rights reserved.",

author = "Ballantyne, {Margaret D} and McDonald, {Robert A} and Baker, {Andrew H}",

note = "BHF: FS/12/66/30003 RG/09/005/27915 FS11/12/28673 ",

year = "2016",

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AU - McDonald, Robert A

AU - Baker, Andrew H

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PY - 2016/3/31

Y1 - 2016/3/31

N2 - MicroRNA (miR) have gained widespread attention for their role in diverse vascular processes including angiogenesis, apoptosis, proliferation and migration. Despite great understanding of microRNA expression and function; knowledge of long non-coding RNA (lncRNA) molecular mechanisms still remains limited. The influence of microRNA on lncRNA function, and the converse, is now beginning to emerge. LncRNA may regulate microRNA function by acting as endogenous sponges to regulate gene expression and microRNA have been shown to bind and regulate lncRNA stability. A detailed understanding of the molecular and cellular effects of lncRNA-microRNA-mediated interactions in vascular pathophysiology could pave the way for new diagnostic markers and therapeutic approaches, but first there is a requirement for a more detailed understanding of the impact of such regulatory networks. This article is protected by copyright. All rights reserved.

AB - MicroRNA (miR) have gained widespread attention for their role in diverse vascular processes including angiogenesis, apoptosis, proliferation and migration. Despite great understanding of microRNA expression and function; knowledge of long non-coding RNA (lncRNA) molecular mechanisms still remains limited. The influence of microRNA on lncRNA function, and the converse, is now beginning to emerge. LncRNA may regulate microRNA function by acting as endogenous sponges to regulate gene expression and microRNA have been shown to bind and regulate lncRNA stability. A detailed understanding of the molecular and cellular effects of lncRNA-microRNA-mediated interactions in vascular pathophysiology could pave the way for new diagnostic markers and therapeutic approaches, but first there is a requirement for a more detailed understanding of the impact of such regulatory networks. This article is protected by copyright. All rights reserved.

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DO - 10.1002/cpt.355

M3 - Literature review

C2 - 26910520

SN - 0009-9236

JO - Clinical Pharmacology & Therapeutics

JF - Clinical Pharmacology & Therapeutics

ER -

LncRNA/microRNA interactions in the vasculature

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