LncRNA/microRNA interactions in the vasculature

Margaret D Ballantyne, Robert A McDonald, Andrew H Baker

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

MicroRNA (miR) have gained widespread attention for their role in diverse vascular processes including angiogenesis, apoptosis, proliferation and migration. Despite great understanding of microRNA expression and function; knowledge of long non-coding RNA (lncRNA) molecular mechanisms still remains limited. The influence of microRNA on lncRNA function, and the converse, is now beginning to emerge. LncRNA may regulate microRNA function by acting as endogenous sponges to regulate gene expression and microRNA have been shown to bind and regulate lncRNA stability. A detailed understanding of the molecular and cellular effects of lncRNA-microRNA-mediated interactions in vascular pathophysiology could pave the way for new diagnostic markers and therapeutic approaches, but first there is a requirement for a more detailed understanding of the impact of such regulatory networks. This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalClinical pharmacology and therapeutics
Early online date31 Mar 2016
DOIs
Publication statusE-pub ahead of print - 31 Mar 2016

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