Abstract
Intra-arterial desmopressin caused dose and time dependent increases (p <0.001 for all) in forearm blood flow (all doses) and plasma tissue plasminogen activator (t-PA) concentrations (desmopressin > or = 70 ng/min). Although plasma t-PA concentrations rose in both forearms, there was a modest local release of t-PA in the infused forearm (14 ng/100 mL of tissue/min, p <0.05). At desmopressin doses > or = 300 ng/min, plasma von Willebrand factor (vWf) and Factor VIII:C concentrations rose in both forearms (p <0.001) and correlated with the rise in interleukin-6 concentrations (r = 0.92, p <0.001: r = 0.85, p = 0.002 respectively). Neither desmopressin nor substance P caused t-PA, vWf or Factor VIII:C release in the patients, although desmopressin increased plasma interleukin-6 concentrations as in healthy volunteers. We conclude that desmopressin releases t-PA, vWf and Factor VIII:C predominantly via systemic mechanisms, possibly mediated by cytokine release. Patients with type 3 vWD appear to have a generalised failure to release t-PA acutely despite a normal interleukin-6 response to desmopressin infusion.
Original language | English |
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Pages (from-to) | 195-203 |
Number of pages | 9 |
Journal | Thrombosis and Haemostasis |
Volume | 84 |
Issue number | 2 |
Publication status | Published - Aug 2000 |
Keywords / Materials (for Non-textual outputs)
- Adult
- Deamino Arginine Vasopressin
- Dose-Response Relationship, Drug
- Factor VIII
- Forearm
- Hemodynamics
- Humans
- Infusions, Intra-Arterial
- Interleukin-6
- Male
- Middle Aged
- Plasminogen Activator Inhibitor 1
- Substance P
- Time Factors
- Tissue Plasminogen Activator
- von Willebrand Diseases
- von Willebrand Factor