Local lung responses following local lung challenge with recombinant lungworm antigen in systemically sensitized sheep

D D Collie, C N MacAldowie, A D Pemberton, C J Woodall, N McLean, C Hodgson, M W Kennedy, H R Miller

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Chronic mast cell-mediated inflammation may contribute significantly towards the extensive tissue remodelling that is a feature of lungworm infection in ruminants. Understanding the factors that control tissue remodelling is a necessary step toward effective management and treatment of conditions that feature such pathology.
Original languageEnglish
Pages (from-to)1636-47
Number of pages12
JournalClinical & Experimental Allergy
Volume31
Issue number10
Publication statusPublished - Oct 2001

Keywords / Materials (for Non-textual outputs)

  • Models, Animal
  • Animals
  • Cell Count
  • Recombinant Proteins
  • Dictyocaulus
  • Sheep
  • Bronchial Provocation Tests
  • Serine Endopeptidases
  • Immunization
  • Leukocyte Count
  • Chymases
  • Neutrophils
  • Lung
  • Eosinophils
  • Bronchoalveolar Lavage Fluid
  • Immunoglobulin G
  • Transforming Growth Factor beta
  • Mast Cells
  • Immunohistochemistry
  • Male
  • Female
  • Antigens, Helminth

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