Abstract / Description of output
The use of reporter genes such as beta-galactosidase and green fluorescent protein is a powerful molecular tool for the visualization of in-vivo gene expression. In this paper, we describe the generation of mice that possess a beta-galactosidase reporter gene introduced into the endothelin-B receptor locus by homologous recombination in embryonic stem cells. These mice express beta- galactosidase wherever endothelin-B is expressed and therefore provide a precise in-vivo localization profile of endothelin-B expression.
Original language | English |
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Pages (from-to) | S144-6 |
Journal | Journal of cardiovascular pharmacology |
Volume | 44 Suppl 1 |
Publication status | Published - 2004 |