Localization of the PGD and TGF beta-1 loci to pig chromosome 6q

M Yerle, A L Archibald, M Dalens, J Gellin

Research output: Contribution to journalArticlepeer-review

Abstract

The TGF beta-1 and PGD loci have been localized by in situ hybridization to the C-greater than q2.1 and q2.2 -greater than q2.5 regions of pig chromosome 6. These assignments confirm that the conversation of syntenic groups around GPI and PGD extends to pigs where these two groups are uniquely found to be linked. Our data also support the hypothesis that the porcine and human inherited malignant hyperthermia syndromes are caused by mutations in homologous genes which map to human chromosome 19q, porcine chromosome 6q and murine chromosome 7.
Original languageEnglish
Pages (from-to)411-7
Number of pages7
JournalAnimal Genetics
Volume21
Issue number4
Publication statusPublished - 1990

Keywords

  • Animals
  • Chromosome Banding
  • Chromosome Mapping
  • Genes
  • Humans
  • Nucleic Acid Hybridization
  • Phosphogluconate Dehydrogenase
  • Swine
  • Transforming Growth Factor beta

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