Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease

Sreekumar G Pillai, Xiangyang Kong, Lisa D Edwards, Michael H Cho, Wayne H Anderson, Harvey O Coxson, David A Lomas, Edwin K Silverman, ECLIPSE and ICGN Investigators, Bill Macnee

Research output: Contribution to journalArticlepeer-review

Abstract

Genome-wide association studies have shown significant associations between variants near hedgehog interacting protein HHIP, FAM13A, and cholinergic nicotinic acetylcholine receptor CHRNA3/5 with increased risk of chronic obstructive pulmonary disease (COPD) in smokers; however, the disease mechanisms behind these associations are not well understood.
Original languageEnglish
Pages (from-to)1498-505
Number of pages8
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume182
Issue number12
DOIs
Publication statusPublished - 2010

Keywords

  • COPD exacerbations
  • nicotine addiction
  • high-resolution CT
  • genetic association analysis
  • emphysema

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