Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease

Sreekumar G Pillai; Xiangyang Kong; Lisa D Edwards; Michael H Cho; Wayne H Anderson; Harvey O Coxson; David A Lomas; Edwin K Silverman; ECLIPSE and ICGN Investigators; Bill Macnee

doi:10.1164/rccm.201002-0151OC

Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease

Sreekumar G Pillai, Xiangyang Kong, Lisa D Edwards, Michael H Cho, Wayne H Anderson, Harvey O Coxson, David A Lomas, Edwin K Silverman, ECLIPSE and ICGN Investigators, Bill Macnee

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Genome-wide association studies have shown significant associations between variants near hedgehog interacting protein HHIP, FAM13A, and cholinergic nicotinic acetylcholine receptor CHRNA3/5 with increased risk of chronic obstructive pulmonary disease (COPD) in smokers; however, the disease mechanisms behind these associations are not well understood.

Original language	English
Pages (from-to)	1498-505
Number of pages	8
Journal	American Journal of Respiratory and Critical Care Medicine
Volume	182
Issue number	12
DOIs	https://doi.org/10.1164/rccm.201002-0151OC
Publication status	Published - 2010

Keywords / Materials (for Non-textual outputs)

COPD exacerbations
nicotine addiction
high-resolution CT
genetic association analysis
emphysema

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10.1164/rccm.201002-0151OC

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Pillai, S. G., Kong, X., Edwards, L. D., Cho, M. H., Anderson, W. H., Coxson, H. O., Lomas, D. A., Silverman, E. K., ECLIPSE and ICGN Investigators, & Macnee, B. (2010). Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 182(12), 1498-505. https://doi.org/10.1164/rccm.201002-0151OC

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title = "Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease",

abstract = "Genome-wide association studies have shown significant associations between variants near hedgehog interacting protein HHIP, FAM13A, and cholinergic nicotinic acetylcholine receptor CHRNA3/5 with increased risk of chronic obstructive pulmonary disease (COPD) in smokers; however, the disease mechanisms behind these associations are not well understood.",

keywords = "COPD exacerbations, nicotine addiction, high-resolution CT, genetic association analysis, emphysema",

author = "Pillai, {Sreekumar G} and Xiangyang Kong and Edwards, {Lisa D} and Cho, {Michael H} and Anderson, {Wayne H} and Coxson, {Harvey O} and Lomas, {David A} and Silverman, {Edwin K} and {ECLIPSE and ICGN Investigators} and Bill Macnee",

year = "2010",

doi = "10.1164/rccm.201002-0151OC",

language = "English",

volume = "182",

pages = "1498--505",

journal = "American Journal of Respiratory and Critical Care Medicine",

issn = "1073-449X",

publisher = "American Thoracic Society",

number = "12",

}

Pillai, SG, Kong, X, Edwards, LD, Cho, MH, Anderson, WH, Coxson, HO, Lomas, DA, Silverman, EK, ECLIPSE and ICGN Investigators & Macnee, B 2010, 'Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease', American Journal of Respiratory and Critical Care Medicine, vol. 182, no. 12, pp. 1498-505. https://doi.org/10.1164/rccm.201002-0151OC

Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease. / Pillai, Sreekumar G; Kong, Xiangyang; Edwards, Lisa D et al.
In: American Journal of Respiratory and Critical Care Medicine, Vol. 182, No. 12, 2010, p. 1498-505.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease

AU - Pillai, Sreekumar G

AU - Kong, Xiangyang

AU - Edwards, Lisa D

AU - Cho, Michael H

AU - Anderson, Wayne H

AU - Coxson, Harvey O

AU - Lomas, David A

AU - Silverman, Edwin K

AU - ECLIPSE and ICGN Investigators

AU - Macnee, Bill

PY - 2010

Y1 - 2010

N2 - Genome-wide association studies have shown significant associations between variants near hedgehog interacting protein HHIP, FAM13A, and cholinergic nicotinic acetylcholine receptor CHRNA3/5 with increased risk of chronic obstructive pulmonary disease (COPD) in smokers; however, the disease mechanisms behind these associations are not well understood.

AB - Genome-wide association studies have shown significant associations between variants near hedgehog interacting protein HHIP, FAM13A, and cholinergic nicotinic acetylcholine receptor CHRNA3/5 with increased risk of chronic obstructive pulmonary disease (COPD) in smokers; however, the disease mechanisms behind these associations are not well understood.

KW - COPD exacerbations

KW - nicotine addiction

KW - high-resolution CT

KW - genetic association analysis

KW - emphysema

U2 - 10.1164/rccm.201002-0151OC

DO - 10.1164/rccm.201002-0151OC

M3 - Article

C2 - 20656943

SN - 1073-449X

VL - 182

SP - 1498

EP - 1505

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

IS - 12

ER -

Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

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