Locomotor recovery following contusive spinal cord injury does not require oligodendrocyte remyelination

Greg J Duncan, Sohrab B Manesh, Brett J Hilton, Peggy Assinck, Jie Liu, Aaron Moulson, Jason R Plemel, Wolfram Tetzlaff

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Remyelination occurs after spinal cord injury (SCI) but its functional relevance is unclear. We assessed the necessity of myelin regulatory factor (Myrf) in remyelination after contusive SCI by deleting the gene from platelet-derived growth factor receptor alpha positive (PDGFRα-positive) oligodendrocyte progenitor cells (OPCs) in mice prior to SCI. While OPC proliferation and density are not altered by Myrf inducible knockout after SCI, the accumulation of new oligodendrocytes is largely prevented. This greatly inhibits myelin regeneration, resulting in a 44% reduction in myelinated axons at the lesion epicenter. However, spontaneous locomotor recovery after SCI is not altered by remyelination failure. In controls with functional MYRF, locomotor recovery precedes the onset of most oligodendrocyte myelin regeneration. Collectively, these data demonstrate that MYRF expression in PDGFRα-positive cell derived oligodendrocytes is indispensable for myelin regeneration following contusive SCI but that oligodendrocyte remyelination is not required for spontaneous recovery of stepping.

Original languageEnglish
Article number3066
Number of pages16
JournalNature Communications
Publication statusPublished - 3 Aug 2018

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Axons/metabolism
  • Behavior, Animal
  • Cell Differentiation
  • Cell Proliferation
  • Disease Models, Animal
  • Female
  • Gene Deletion
  • Male
  • Mice
  • Mice, Knockout
  • Myelin Sheath/metabolism
  • Nerve Regeneration/physiology
  • Neural Stem Cells/pathology
  • Oligodendroglia/metabolism
  • Receptor, Platelet-Derived Growth Factor alpha
  • Remyelination/physiology
  • Spinal Cord/metabolism
  • Spinal Cord Injuries/metabolism
  • Transcription Factors/genetics


Dive into the research topics of 'Locomotor recovery following contusive spinal cord injury does not require oligodendrocyte remyelination'. Together they form a unique fingerprint.

Cite this