Long COVID and cardiovascular disease: a prospective cohort study

PHOSP-COVID Study Collaborative Group; Claire Alexandra Lawson; Alastair James Moss; Jayanth Ranjit Arnold; Catherine Bagot; Amitava Banerjee; Colin Berry; John Greenwood; Alun D Hughes; Kamlesh Khunti; Nicholas L Mills; Stefan Neubauer; Betty Raman; Naveed Sattar; Olivia C Leavy; Matthew Richardson; Omer Elneima; Hamish Jc McAuley; Aarti Shikotra; Amisha Singapuri; Marco Sereno; Ruth Saunders; Victoria Harris; Linzy Houchen-Wolloff; Neil J Greening; Ewen Harrison; Annemarie B Docherty; Nazir I Lone; Jennifer Kathleen Quint; James Chalmers; Ling-Pei Ho; Alex Horsley; Michael Marks; Krisnah Poinasamy; Rachael Evans; Louise V Wain; Chris Brightling; Gerry P McCann

doi:10.1136/openhrt-2024-002662

Long COVID and cardiovascular disease: a prospective cohort study

PHOSP-COVID Study Collaborative Group, Claire Alexandra Lawson, Alastair James Moss, Jayanth Ranjit Arnold, Catherine Bagot, Amitava Banerjee, Colin Berry, John Greenwood, Alun D Hughes, Kamlesh Khunti, Nicholas L Mills, Stefan Neubauer, Betty Raman, Naveed Sattar, Olivia C Leavy, Matthew Richardson, Omer Elneima, Hamish Jc McAuley, Aarti Shikotra, Amisha SingapuriMarco Sereno, Ruth Saunders, Victoria Harris, Linzy Houchen-Wolloff, Neil J Greening, Ewen Harrison, Annemarie B Docherty, Nazir I Lone, Jennifer Kathleen Quint, James Chalmers, Ling-Pei Ho, Alex Horsley, Michael Marks, Krisnah Poinasamy, Rachael Evans, Louise V Wain, Chris Brightling, Gerry P McCann^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

BACKGROUND: Pre-existing cardiovascular disease (CVD) or cardiovascular risk factors have been associated with an increased risk of complications following hospitalisation with COVID-19, but their impact on the rate of recovery following discharge is not known.

OBJECTIVES: To determine whether the rate of patient-perceived recovery following hospitalisation with COVID-19 was affected by the presence of CVD or cardiovascular risk factors.

METHODS: In a multicentre prospective cohort study, patients were recruited following discharge from the hospital with COVID-19 undertaking two comprehensive assessments at 5 months and 12 months. Patients were stratified by the presence of either CVD or cardiovascular risk factors prior to hospitalisation with COVID-19 and compared with controls with neither. Full recovery was determined by the response to a patient-perceived evaluation of full recovery from COVID-19 in the context of physical, physiological and cognitive determinants of health.

RESULTS: From a total population of 2545 patients (38.8% women), 472 (18.5%) and 1355 (53.2%) had CVD or cardiovascular risk factors, respectively. Compared with controls (n=718), patients with CVD and cardiovascular risk factors were older and more likely to have had severe COVID-19. Full recovery was significantly lower at 12 months in patients with CVD (adjusted OR (aOR) 0.62, 95% CI 0.43 to 0.89) and cardiovascular risk factors (aOR 0.66, 95% CI 0.50 to 0.86).

CONCLUSION: Patients with CVD or cardiovascular risk factors had a delayed recovery at 12 months following hospitalisation with COVID-19. Targeted interventions to reduce the impact of COVID-19 in patients with cardiovascular disease remain an unmet need.

TRAIL REGISTRATION NUMBER: ISRCTN10980107.

Original language	English
Article number	e002662
Journal	Open heart
Volume	11
Issue number	1
DOIs	https://doi.org/10.1136/openhrt-2024-002662
Publication status	Published - 27 May 2024

Keywords / Materials (for Non-textual outputs)

Humans
COVID-19/epidemiology
Male
Female
Cardiovascular Diseases/epidemiology
Prospective Studies
Middle Aged
Aged
Risk Factors
Hospitalization/statistics & numerical data
Time Factors
SARS-CoV-2
Recovery of Function

Access to Document

10.1136/openhrt-2024-002662Licence: Creative Commons: Attribution (CC-BY)

e002662.fullFinal published version, 1.49 MBLicence: Creative Commons: Attribution (CC-BY)

1 Finished
1 Active

High-Sensitivity Cardiac Troponin Beyond the Acute Coronary Syndrome
Mills, N., Anand, A., Chapman, A., Ferry, A., Newby, D., Strachan, F. & Tsanas, T.
UK-based charities
1/06/20 → 31/05/25
Project: Research
Process mining and point-of-care diagnostic testing to design rapid access chest pain services of the future
Mills, N.
British Heart Foundation
1/08/22 → 31/10/23
Project: Research

Cite this

PHOSP-COVID Study Collaborative Group, Lawson, C. A., Moss, A. J., Arnold, J. R., Bagot, C., Banerjee, A., Berry, C., Greenwood, J., Hughes, A. D., Khunti, K., Mills, N. L., Neubauer, S., Raman, B., Sattar, N., Leavy, O. C., Richardson, M., Elneima, O., McAuley, H. J., Shikotra, A., ... McCann, G. P. (2024). Long COVID and cardiovascular disease: a prospective cohort study. Open heart, 11(1), Article e002662. https://doi.org/10.1136/openhrt-2024-002662

@article{b81109e9fb3442e5b03fe4738ce7e6a5,

title = "Long COVID and cardiovascular disease: a prospective cohort study",

abstract = "BACKGROUND: Pre-existing cardiovascular disease (CVD) or cardiovascular risk factors have been associated with an increased risk of complications following hospitalisation with COVID-19, but their impact on the rate of recovery following discharge is not known.OBJECTIVES: To determine whether the rate of patient-perceived recovery following hospitalisation with COVID-19 was affected by the presence of CVD or cardiovascular risk factors.METHODS: In a multicentre prospective cohort study, patients were recruited following discharge from the hospital with COVID-19 undertaking two comprehensive assessments at 5 months and 12 months. Patients were stratified by the presence of either CVD or cardiovascular risk factors prior to hospitalisation with COVID-19 and compared with controls with neither. Full recovery was determined by the response to a patient-perceived evaluation of full recovery from COVID-19 in the context of physical, physiological and cognitive determinants of health.RESULTS: From a total population of 2545 patients (38.8% women), 472 (18.5%) and 1355 (53.2%) had CVD or cardiovascular risk factors, respectively. Compared with controls (n=718), patients with CVD and cardiovascular risk factors were older and more likely to have had severe COVID-19. Full recovery was significantly lower at 12 months in patients with CVD (adjusted OR (aOR) 0.62, 95% CI 0.43 to 0.89) and cardiovascular risk factors (aOR 0.66, 95% CI 0.50 to 0.86).CONCLUSION: Patients with CVD or cardiovascular risk factors had a delayed recovery at 12 months following hospitalisation with COVID-19. Targeted interventions to reduce the impact of COVID-19 in patients with cardiovascular disease remain an unmet need.TRAIL REGISTRATION NUMBER: ISRCTN10980107.",

keywords = "Humans, COVID-19/epidemiology, Male, Female, Cardiovascular Diseases/epidemiology, Prospective Studies, Middle Aged, Aged, Risk Factors, Hospitalization/statistics & numerical data, Time Factors, SARS-CoV-2, Recovery of Function",

author = "{PHOSP-COVID Study Collaborative Group} and Lawson, {Claire Alexandra} and Moss, {Alastair James} and Arnold, {Jayanth Ranjit} and Catherine Bagot and Amitava Banerjee and Colin Berry and John Greenwood and Hughes, {Alun D} and Kamlesh Khunti and Mills, {Nicholas L} and Stefan Neubauer and Betty Raman and Naveed Sattar and Leavy, {Olivia C} and Matthew Richardson and Omer Elneima and McAuley, {Hamish Jc} and Aarti Shikotra and Amisha Singapuri and Marco Sereno and Ruth Saunders and Victoria Harris and Linzy Houchen-Wolloff and Greening, {Neil J} and Ewen Harrison and Docherty, {Annemarie B} and Lone, {Nazir I} and Quint, {Jennifer Kathleen} and James Chalmers and Ling-Pei Ho and Alex Horsley and Michael Marks and Krisnah Poinasamy and Rachael Evans and Wain, {Louise V} and Chris Brightling and McCann, {Gerry P}",

note = "{\textcopyright} Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.",

year = "2024",

month = may,

day = "27",

doi = "10.1136/openhrt-2024-002662",

language = "English",

volume = "11",

journal = "Open heart",

issn = "2053-3624",

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PHOSP-COVID Study Collaborative Group, Lawson, CA, Moss, AJ, Arnold, JR, Bagot, C, Banerjee, A, Berry, C, Greenwood, J, Hughes, AD, Khunti, K, Mills, NL, Neubauer, S, Raman, B, Sattar, N, Leavy, OC, Richardson, M, Elneima, O, McAuley, HJ, Shikotra, A, Singapuri, A, Sereno, M, Saunders, R, Harris, V, Houchen-Wolloff, L, Greening, NJ, Harrison, E , Docherty, AB , Lone, NI, Quint, JK, Chalmers, J, Ho, L-P, Horsley, A, Marks, M, Poinasamy, K, Evans, R, Wain, LV, Brightling, C & McCann, GP 2024, 'Long COVID and cardiovascular disease: a prospective cohort study', Open heart, vol. 11, no. 1, e002662. https://doi.org/10.1136/openhrt-2024-002662

TY - JOUR

T1 - Long COVID and cardiovascular disease

T2 - a prospective cohort study

AU - PHOSP-COVID Study Collaborative Group

AU - Lawson, Claire Alexandra

AU - Moss, Alastair James

AU - Arnold, Jayanth Ranjit

AU - Bagot, Catherine

AU - Banerjee, Amitava

AU - Berry, Colin

AU - Greenwood, John

AU - Hughes, Alun D

AU - Khunti, Kamlesh

AU - Mills, Nicholas L

AU - Neubauer, Stefan

AU - Raman, Betty

AU - Sattar, Naveed

AU - Leavy, Olivia C

AU - Richardson, Matthew

AU - Elneima, Omer

AU - McAuley, Hamish Jc

AU - Shikotra, Aarti

AU - Singapuri, Amisha

AU - Sereno, Marco

AU - Saunders, Ruth

AU - Harris, Victoria

AU - Houchen-Wolloff, Linzy

AU - Greening, Neil J

AU - Harrison, Ewen

AU - Docherty, Annemarie B

AU - Lone, Nazir I

AU - Quint, Jennifer Kathleen

AU - Chalmers, James

AU - Ho, Ling-Pei

AU - Horsley, Alex

AU - Marks, Michael

AU - Poinasamy, Krisnah

AU - Evans, Rachael

AU - Wain, Louise V

AU - Brightling, Chris

AU - McCann, Gerry P

PY - 2024/5/27

Y1 - 2024/5/27

N2 - BACKGROUND: Pre-existing cardiovascular disease (CVD) or cardiovascular risk factors have been associated with an increased risk of complications following hospitalisation with COVID-19, but their impact on the rate of recovery following discharge is not known.OBJECTIVES: To determine whether the rate of patient-perceived recovery following hospitalisation with COVID-19 was affected by the presence of CVD or cardiovascular risk factors.METHODS: In a multicentre prospective cohort study, patients were recruited following discharge from the hospital with COVID-19 undertaking two comprehensive assessments at 5 months and 12 months. Patients were stratified by the presence of either CVD or cardiovascular risk factors prior to hospitalisation with COVID-19 and compared with controls with neither. Full recovery was determined by the response to a patient-perceived evaluation of full recovery from COVID-19 in the context of physical, physiological and cognitive determinants of health.RESULTS: From a total population of 2545 patients (38.8% women), 472 (18.5%) and 1355 (53.2%) had CVD or cardiovascular risk factors, respectively. Compared with controls (n=718), patients with CVD and cardiovascular risk factors were older and more likely to have had severe COVID-19. Full recovery was significantly lower at 12 months in patients with CVD (adjusted OR (aOR) 0.62, 95% CI 0.43 to 0.89) and cardiovascular risk factors (aOR 0.66, 95% CI 0.50 to 0.86).CONCLUSION: Patients with CVD or cardiovascular risk factors had a delayed recovery at 12 months following hospitalisation with COVID-19. Targeted interventions to reduce the impact of COVID-19 in patients with cardiovascular disease remain an unmet need.TRAIL REGISTRATION NUMBER: ISRCTN10980107.

AB - BACKGROUND: Pre-existing cardiovascular disease (CVD) or cardiovascular risk factors have been associated with an increased risk of complications following hospitalisation with COVID-19, but their impact on the rate of recovery following discharge is not known.OBJECTIVES: To determine whether the rate of patient-perceived recovery following hospitalisation with COVID-19 was affected by the presence of CVD or cardiovascular risk factors.METHODS: In a multicentre prospective cohort study, patients were recruited following discharge from the hospital with COVID-19 undertaking two comprehensive assessments at 5 months and 12 months. Patients were stratified by the presence of either CVD or cardiovascular risk factors prior to hospitalisation with COVID-19 and compared with controls with neither. Full recovery was determined by the response to a patient-perceived evaluation of full recovery from COVID-19 in the context of physical, physiological and cognitive determinants of health.RESULTS: From a total population of 2545 patients (38.8% women), 472 (18.5%) and 1355 (53.2%) had CVD or cardiovascular risk factors, respectively. Compared with controls (n=718), patients with CVD and cardiovascular risk factors were older and more likely to have had severe COVID-19. Full recovery was significantly lower at 12 months in patients with CVD (adjusted OR (aOR) 0.62, 95% CI 0.43 to 0.89) and cardiovascular risk factors (aOR 0.66, 95% CI 0.50 to 0.86).CONCLUSION: Patients with CVD or cardiovascular risk factors had a delayed recovery at 12 months following hospitalisation with COVID-19. Targeted interventions to reduce the impact of COVID-19 in patients with cardiovascular disease remain an unmet need.TRAIL REGISTRATION NUMBER: ISRCTN10980107.

KW - Humans

KW - COVID-19/epidemiology

KW - Male

KW - Female

KW - Cardiovascular Diseases/epidemiology

KW - Prospective Studies

KW - Middle Aged

KW - Aged

KW - Risk Factors

KW - Hospitalization/statistics & numerical data

KW - Time Factors

KW - SARS-CoV-2

KW - Recovery of Function

U2 - 10.1136/openhrt-2024-002662

DO - 10.1136/openhrt-2024-002662

M3 - Article

C2 - 38802280

SN - 2053-3624

VL - 11

JO - Open heart

JF - Open heart

IS - 1

M1 - e002662

ER -

Long COVID and cardiovascular disease: a prospective cohort study

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

Fingerprint

Projects

High-Sensitivity Cardiac Troponin Beyond the Acute Coronary Syndrome

Process mining and point-of-care diagnostic testing to design rapid access chest pain services of the future

Cite this