Long-term cancer risk of the anorectal cuff following restorative proctocolectomy assessed by p53 expression and cuff dysplasia

D B Coull, F D Lee, J H Anderson, R F McKee, I G Finlay, M G Dunlop

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Restorative proctocolectomy (RP) for ulcerative colitis (UC) retains a 'cuff' of columnar rectal epithelium that has unknown risk of malignant change. Markers of malignant potential in UC include aberrant p53 expression and dysplasia. We undertook a prospective study comprising serial surveillance biopsy and assessed the occurrence of aberrant p53 expression, epithelial dysplasia and carcinoma in the retained anorectal cuff following stapled RP.
Original languageEnglish
Pages (from-to)321-7
Number of pages7
JournalColorectal Disease
Volume9
Issue number4
DOIs
Publication statusPublished - 2007

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