Long-term childhood outcomes after interventions for prevention and management of preterm birth

Research output: Contribution to journalArticlepeer-review

Abstract

Globally, preterm birth rates are rising and have a significant impact on neonatal morbidity and mortality. Preterm birth remains difficult to prevent and a number of strategies for preterm birth prevention (progesterone, cervical pessaries, cervical cerclage, tocolytics, and antibiotics) have been identified. While some of these show more promise, there is a paucity of evidence regarding the long-term effects of these strategies on childhood outcomes. Strategies used to improve the health of babies if born preterm, such as antenatal magnesium sulfate for fetal neuroprotection and antenatal corticosteroids for fetal lung maturation, show evidence of short-term benefit but lack large-scale follow-up data of long-term childhood outcomes. Future research on preterm birth interventions should include long-term follow-up of the children, ideally with similar outcome measures to allow for future meta-analyses.

Original languageEnglish
Pages (from-to)519-527
Number of pages9
JournalSeminars in perinatology
Volume41
Issue number8
Early online date1 Dec 2017
DOIs
Publication statusPublished - Dec 2017

Keywords

  • Journal Article
  • Review

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