Long-term endoscopic management of upper tract urothelial carcinoma: 20-year single-centre experience

Mark L Cutress, Grant D Stewart, Simon Wells-Cole, Simon Phipps, Ben G Thomas, David A Tolley

Research output: Contribution to journalArticlepeer-review

Abstract

What's known on the subject? and What does the study add?

Endoscopic management of small, low-grade, non-invasive upper tract urothelial cell carcinoma (UTUC) is a management option for selected groups of patients. However, the long-term survival outcomes of endoscopically-managed UTUC are uncertain because only four institutions have reported outcomes of more than 40 patients beyond 50 months of follow-up. Moreover, there is significant variance in the degree of underlying UTUC pathology verification in some of these reports, which precludes an analysis of disease-specific survival outcomes. The present study represents one of the largest endoscopically managed series of patients with UTUC, with a long-term follow-up. The degree of verification of underlying UTUC pathology is one of the highest, which allows a grade-stratified analysis of different outcomes, including upper-tract recurrence-free survival, intravesical recurrence-free survival, renal unit survival and disease-specific survival. These outcomes provide further evidence suggesting that endoscopic management of highly selected, low-grade UTUC can provide effective oncological control, as well as renal preservation, in experienced centres.
Original languageEnglish
Pages (from-to)1608-1617
Number of pages10
JournalBJU International
Volume110
Issue number11
DOIs
Publication statusPublished - Dec 2012

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Transitional Cell
  • Chemotherapy, Adjuvant
  • Epidemiologic Methods
  • Female
  • Humans
  • Kidney Neoplasms
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Postoperative Complications
  • Treatment Outcome
  • Ureteral Neoplasms
  • Ureteroscopy
  • Urinary Bladder Neoplasms

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