Long-term intracerebral inflammatory response after traumatic brain injury

S M Gentleman, P D Leclercq, L Moyes, D I Graham, C Smith, W S T Griffin, J A R Nicoll

Research output: Contribution to journalArticlepeer-review

Abstract

Epidemiological and pathological studies suggest that head injury is a significant risk factor for subsequent neurodegeneration and cognitive decline in later life. The precise mechanisms for the development of post-traumatic neurodegenerative change are unclear but we hypothesize that persistence of inflammatory processes in the brain may play a key role and that some individuals are more susceptible to such changes based on their genetic make-up. In support of this hypothesis we present evidence of persistent elevated microglial activity in long-term survivors of head injury and the suggestion of an association between the extent of this activity and interleukin-1 genotype.
Original languageEnglish
Pages (from-to)97-104
Number of pages8
JournalForensic Science International
Volume146
Issue number2-3
DOIs
Publication statusPublished - 16 Dec 2004

Keywords

  • Adolescent
  • Adult
  • Aged
  • Alleles
  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • Apolipoproteins E
  • Biological Markers
  • Brain
  • Brain Injuries
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Female
  • Forensic Pathology
  • Genotype
  • Humans
  • Hyperplasia
  • Hypertrophy
  • Infant
  • Inflammation
  • Interleukin-1
  • Macrophage-1 Antigen
  • Male
  • Microglia
  • Middle Aged
  • Phagocytosis
  • Survival Analysis

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