Long-term intracerebral inflammatory response after traumatic brain injury

S M Gentleman; P D Leclercq; L Moyes; D I Graham; C Smith; W S T Griffin; J A R Nicoll

doi:10.1016/j.forsciint.2004.06.027

Long-term intracerebral inflammatory response after traumatic brain injury

S M Gentleman, P D Leclercq, L Moyes, D I Graham, C Smith, W S T Griffin, J A R Nicoll

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Epidemiological and pathological studies suggest that head injury is a significant risk factor for subsequent neurodegeneration and cognitive decline in later life. The precise mechanisms for the development of post-traumatic neurodegenerative change are unclear but we hypothesize that persistence of inflammatory processes in the brain may play a key role and that some individuals are more susceptible to such changes based on their genetic make-up. In support of this hypothesis we present evidence of persistent elevated microglial activity in long-term survivors of head injury and the suggestion of an association between the extent of this activity and interleukin-1 genotype.

Original language	English
Pages (from-to)	97-104
Number of pages	8
Journal	Forensic Science International
Volume	146
Issue number	2-3
DOIs	https://doi.org/10.1016/j.forsciint.2004.06.027
Publication status	Published - 16 Dec 2004

Keywords / Materials (for Non-textual outputs)

Adolescent
Adult
Aged
Alleles
Antigens, CD
Antigens, Differentiation, Myelomonocytic
Apolipoproteins E
Biological Markers
Brain
Brain Injuries
Case-Control Studies
Child
Child, Preschool
Female
Forensic Pathology
Genotype
Humans
Hyperplasia
Hypertrophy
Infant
Inflammation
Interleukin-1
Macrophage-1 Antigen
Male
Microglia
Middle Aged
Phagocytosis
Survival Analysis

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10.1016/j.forsciint.2004.06.027

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title = "Long-term intracerebral inflammatory response after traumatic brain injury",

abstract = "Epidemiological and pathological studies suggest that head injury is a significant risk factor for subsequent neurodegeneration and cognitive decline in later life. The precise mechanisms for the development of post-traumatic neurodegenerative change are unclear but we hypothesize that persistence of inflammatory processes in the brain may play a key role and that some individuals are more susceptible to such changes based on their genetic make-up. In support of this hypothesis we present evidence of persistent elevated microglial activity in long-term survivors of head injury and the suggestion of an association between the extent of this activity and interleukin-1 genotype.",

keywords = "Adolescent, Adult, Aged, Alleles, Antigens, CD, Antigens, Differentiation, Myelomonocytic, Apolipoproteins E, Biological Markers, Brain, Brain Injuries, Case-Control Studies, Child, Child, Preschool, Female, Forensic Pathology, Genotype, Humans, Hyperplasia, Hypertrophy, Infant, Inflammation, Interleukin-1, Macrophage-1 Antigen, Male, Microglia, Middle Aged, Phagocytosis, Survival Analysis",

author = "Gentleman, {S M} and Leclercq, {P D} and L Moyes and Graham, {D I} and C Smith and Griffin, {W S T} and Nicoll, {J A R}",

year = "2004",

month = dec,

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doi = "10.1016/j.forsciint.2004.06.027",

language = "English",

volume = "146",

pages = "97--104",

journal = "Forensic Science International",

issn = "0379-0738",

publisher = "Elsevier Ireland Ltd",

number = "2-3",

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TY - JOUR

T1 - Long-term intracerebral inflammatory response after traumatic brain injury

AU - Gentleman, S M

AU - Leclercq, P D

AU - Moyes, L

AU - Graham, D I

AU - Smith, C

AU - Griffin, W S T

AU - Nicoll, J A R

PY - 2004/12/16

Y1 - 2004/12/16

N2 - Epidemiological and pathological studies suggest that head injury is a significant risk factor for subsequent neurodegeneration and cognitive decline in later life. The precise mechanisms for the development of post-traumatic neurodegenerative change are unclear but we hypothesize that persistence of inflammatory processes in the brain may play a key role and that some individuals are more susceptible to such changes based on their genetic make-up. In support of this hypothesis we present evidence of persistent elevated microglial activity in long-term survivors of head injury and the suggestion of an association between the extent of this activity and interleukin-1 genotype.

AB - Epidemiological and pathological studies suggest that head injury is a significant risk factor for subsequent neurodegeneration and cognitive decline in later life. The precise mechanisms for the development of post-traumatic neurodegenerative change are unclear but we hypothesize that persistence of inflammatory processes in the brain may play a key role and that some individuals are more susceptible to such changes based on their genetic make-up. In support of this hypothesis we present evidence of persistent elevated microglial activity in long-term survivors of head injury and the suggestion of an association between the extent of this activity and interleukin-1 genotype.

KW - Adolescent

KW - Adult

KW - Aged

KW - Alleles

KW - Antigens, CD

KW - Antigens, Differentiation, Myelomonocytic

KW - Apolipoproteins E

KW - Biological Markers

KW - Brain

KW - Brain Injuries

KW - Case-Control Studies

KW - Child

KW - Child, Preschool

KW - Female

KW - Forensic Pathology

KW - Genotype

KW - Humans

KW - Hyperplasia

KW - Hypertrophy

KW - Infant

KW - Inflammation

KW - Interleukin-1

KW - Macrophage-1 Antigen

KW - Male

KW - Microglia

KW - Middle Aged

KW - Phagocytosis

KW - Survival Analysis

U2 - 10.1016/j.forsciint.2004.06.027

DO - 10.1016/j.forsciint.2004.06.027

M3 - Article

C2 - 15542269

SN - 0379-0738

VL - 146

SP - 97

EP - 104

JO - Forensic Science International

JF - Forensic Science International

IS - 2-3

ER -

Long-term intracerebral inflammatory response after traumatic brain injury

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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