Long-term levetiracetam treatment affects reproductive endocrine function in female Wistar rats

Sigrid Svalheim, Erik Taubøll, Kristina Surdova, Lasse Ormel, Ellen Dahl, Mona Aleksandersen, Alan McNeilly, Leif Gjerstad, Erik Ropstad

Research output: Contribution to journalArticlepeer-review

Abstract

Several antiepileptic drugs (AEDs) induce changes in endocrine function in women with epilepsy. Levetiracetam (LEV) is one of the newer AEDs, and to date no endocrine side-effects have been reported in humans. However, a recent study on ovarian follicular cells from prepubertal pigs showed that LEV affected basal steroid hormone secretion. The aim of the present study was to investigate possible effects of the drug on endocrine function and ovarian morphology in non-epileptic rats.
Original languageEnglish
Pages (from-to)203-9
Number of pages7
JournalSeizure - European Journal of Epilepsy
Volume17
Issue number2
DOIs
Publication statusPublished - Mar 2008

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