LONG-TERM PROGNOSTIC-SIGNIFICANCE OF THYMIDINE LABELING INDEX IN PRIMARY BREAST-CANCER

TG COOKE*, PD STANTON, J WINSTANLEY, GD MURRAY, R CROTON, S HOLT, WD GEORGE

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Tumour growth rates, as measured by incorporation of tritiated thymidine, have been reported as being of prognostic importance in breast cancer. We have measured the thymidine labelling index (TLI) of 185 early breast cancers, followed-up for a minimum of 8 years. Above median TLI was associated with higher tumour grade, but not with other prognostic factors. TLI was not predictive of survival in either univariate or multivariate analysis. The inter- and intra-observer reproducibilities of TLI measurements were poor, which may be a factor limiting its usefulness as a prognostic indicator in breast cancer.

Original languageEnglish
Pages (from-to)424-426
Number of pages3
JournalEuropean Journal of Cancer
Volume28A
Issue number2-3
Publication statusPublished - 1992
EventBREAST CANCER WORKING CONF : BREAST CANCER - LOTS OF DATA, STEADY BUT SLOW CLINICAL PROGRESS - LOUVAIN, Belgium
Duration: 3 Sept 19916 Sept 1991

Keywords / Materials (for Non-textual outputs)

  • LABELING INDEX
  • CARCINOMA

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