Longevity candidate genes and their association with personality traits in the elderly

Michelle Luciano; Lorna M Lopez; Marleen H M de Moor; Sarah E Harris; Gail Davies; Teresa Nutile; Robert F Krueger; Tõnu Esko; David Schlessinger; Tanaka Toshiko; Jaime L Derringer; Anu Realo; Narelle K Hansell; Michele L Pergadia; Anu-Katriina Pesonen; Serena Sanna; Antonio Terracciano; Pamela A F Madden; Brenda Penninx; Philip Spinhoven; Catherina A Hartman; Ben A Oostra; A Cecile J W Janssens; Johan G Eriksson; John Starr; Alessandra Cannas; Luigi Ferrucci; Andres Metspalu; Margeret J Wright; Andrew C Heath; Cornelia M van Duijn; Laura J Bierut; Katri Raikkonen; Nicholas G Martin; Marina Ciullo; Dan Rujescu; Dorret I Boomsma; Ian J Deary

doi:10.1002/ajmg.b.32013

Longevity candidate genes and their association with personality traits in the elderly

Michelle Luciano, Lorna M Lopez, Marleen H M de Moor, Sarah E Harris, Gail Davies, Teresa Nutile, Robert F Krueger, Tõnu Esko, David Schlessinger, Tanaka Toshiko, Jaime L Derringer, Anu Realo, Narelle K Hansell, Michele L Pergadia, Anu-Katriina Pesonen, Serena Sanna, Antonio Terracciano, Pamela A F Madden, Brenda Penninx, Philip SpinhovenCatherina A Hartman, Ben A Oostra, A Cecile J W Janssens, Johan G Eriksson, John Starr, Alessandra Cannas, Luigi Ferrucci, Andres Metspalu, Margeret J Wright, Andrew C Heath, Cornelia M van Duijn, Laura J Bierut, Katri Raikkonen, Nicholas G Martin, Marina Ciullo, Dan Rujescu, Dorret I Boomsma, Ian J Deary

Research output: Contribution to journal › Article › peer-review

Abstract

Human longevity and personality traits are both heritable and are consistently linked at the phenotypic level. We test the hypothesis that candidate genes influencing longevity in lower organisms are associated with variance in the five major dimensions of human personality (measured by the NEO-FFI and IPIP inventories) plus related mood states of anxiety and depression. Seventy single nucleotide polymorphisms (SNPs) in six brain expressed, longevity candidate genes (AFG3L2, FRAP1, MAT1A, MAT2A, SYNJ1, and SYNJ2) were typed in over 1,000 70-year old participants from the Lothian Birth Cohort of 1936 (LBC1936). No SNPs were associated with the personality and psychological distress traits at a Bonferroni corrected level of significance (P 60 years). Because we selected a specific set of longevity genes based on functional genomics findings, further research on other longevity gene candidates is warranted to discover whether they are relevant candidates for personality and psychological distress traits. © 2011 Wiley Periodicals, Inc.

Original language	English
Pages (from-to)	192-200
Number of pages	9
Journal	American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume	159B
Issue number	2
Early online date	5 Dec 2011
DOIs	https://doi.org/10.1002/ajmg.b.32013
Publication status	Published - Mar 2012

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Luciano, M., Lopez, L. M., de Moor, M. H. M., Harris, S. E., Davies, G., Nutile, T., Krueger, R. F., Esko, T., Schlessinger, D., Toshiko, T., Derringer, J. L., Realo, A., Hansell, N. K., Pergadia, M. L., Pesonen, A.-K., Sanna, S., Terracciano, A., Madden, P. A. F., Penninx, B., ... Deary, I. J. (2012). Longevity candidate genes and their association with personality traits in the elderly. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 159B(2), 192-200. https://doi.org/10.1002/ajmg.b.32013

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abstract = "Human longevity and personality traits are both heritable and are consistently linked at the phenotypic level. We test the hypothesis that candidate genes influencing longevity in lower organisms are associated with variance in the five major dimensions of human personality (measured by the NEO-FFI and IPIP inventories) plus related mood states of anxiety and depression. Seventy single nucleotide polymorphisms (SNPs) in six brain expressed, longevity candidate genes (AFG3L2, FRAP1, MAT1A, MAT2A, SYNJ1, and SYNJ2) were typed in over 1,000 70-year old participants from the Lothian Birth Cohort of 1936 (LBC1936). No SNPs were associated with the personality and psychological distress traits at a Bonferroni corrected level of significance (P 60 years). Because we selected a specific set of longevity genes based on functional genomics findings, further research on other longevity gene candidates is warranted to discover whether they are relevant candidates for personality and psychological distress traits. {\textcopyright} 2011 Wiley Periodicals, Inc.",

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Luciano, M, Lopez, LM, de Moor, MHM, Harris, SE , Davies, G, Nutile, T, Krueger, RF, Esko, T, Schlessinger, D, Toshiko, T, Derringer, JL, Realo, A, Hansell, NK, Pergadia, ML, Pesonen, A-K, Sanna, S, Terracciano, A, Madden, PAF, Penninx, B, Spinhoven, P, Hartman, CA, Oostra, BA, Janssens, ACJW, Eriksson, JG, Starr, J, Cannas, A, Ferrucci, L, Metspalu, A, Wright, MJ, Heath, AC, van Duijn, CM, Bierut, LJ, Raikkonen, K, Martin, NG, Ciullo, M, Rujescu, D, Boomsma, DI & Deary, IJ 2012, 'Longevity candidate genes and their association with personality traits in the elderly', American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, vol. 159B, no. 2, pp. 192-200. https://doi.org/10.1002/ajmg.b.32013

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AU - Luciano, Michelle

AU - Lopez, Lorna M

AU - de Moor, Marleen H M

AU - Harris, Sarah E

AU - Davies, Gail

AU - Nutile, Teresa

AU - Krueger, Robert F

AU - Esko, Tõnu

AU - Schlessinger, David

AU - Toshiko, Tanaka

AU - Derringer, Jaime L

AU - Realo, Anu

AU - Hansell, Narelle K

AU - Pergadia, Michele L

AU - Pesonen, Anu-Katriina

AU - Sanna, Serena

AU - Terracciano, Antonio

AU - Madden, Pamela A F

AU - Penninx, Brenda

AU - Spinhoven, Philip

AU - Hartman, Catherina A

AU - Oostra, Ben A

AU - Janssens, A Cecile J W

AU - Eriksson, Johan G

AU - Starr, John

AU - Cannas, Alessandra

AU - Ferrucci, Luigi

AU - Metspalu, Andres

AU - Wright, Margeret J

AU - Heath, Andrew C

AU - van Duijn, Cornelia M

AU - Bierut, Laura J

AU - Raikkonen, Katri

AU - Martin, Nicholas G

AU - Ciullo, Marina

AU - Rujescu, Dan

AU - Boomsma, Dorret I

AU - Deary, Ian J

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Longevity candidate genes and their association with personality traits in the elderly

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Disconnected Mind [Phase 2]

A Hundred at Ninety: the common cause Hypothesis of Ageing tested in four waves of the Lothian Birth Cohort 1921

A genome wide association study of non pathological cognitive ageing

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Longevity candidate genes and their association with personality traits in the elderly

Abstract

Access to Document

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Fingerprint

Projects

Disconnected Mind [Phase 2]

A Hundred at Ninety: the common cause Hypothesis of Ageing tested in four waves of the Lothian Birth Cohort 1921

A genome wide association study of non pathological cognitive ageing

Cite this