Abstract / Description of output
Preterm birth is a significant public health concern. For infants born very preterm (≤ 32 weeks completed gestation), there is a high instance of developmental disability. Due to the heterogeneity of patient outcomes, it is important to investigate early markers of future ability to provide effective and targeted intervention. As a neuronal relay centre, the thalamus is critical for effective cognitive function and, thus, development of white matter connections between the thalamus and cortex is vital. By non-invasively examining the state of the thalamus we can monitor development in the preterm period. To track the development we develop a novel registration technique to combine data from multiple modalities, in order to derive the transformation from a preterm scan, to a scan of the same infant at term-equivalent age. By measuring the changes in diffusion parameters over this period on a per-voxel basis, we hope to provide unique insight into neurodevelopment.
Original language | English |
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Pages (from-to) | 276-83 |
Number of pages | 8 |
Journal | Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention |
Volume | 17 |
Issue number | Pt 2 |
DOIs | |
Publication status | Published - 2014 |
Keywords / Materials (for Non-textual outputs)
- Aging/pathology
- Brain/pathology
- Diffusion Tensor Imaging/methods
- Female
- Gray Matter/pathology
- Humans
- Infant, Premature
- Longitudinal Studies
- Male
- Multimodal Imaging/methods
- Nerve Fibers, Myelinated/pathology
- Pattern Recognition, Automated/methods
- Reproducibility of Results
- Sensitivity and Specificity
- Thalamus/pathology