Longitudinal profiling of circulating tumour DNA for tracking tumour dynamics in pancreatic cancer

Lavanya Sivapalan, Graeme J. Thorn, Emanuela Gadaleta, Hemant M. Kocher, Helen Ross-Adams, Claude Chelala

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The utility of circulating tumour DNA (ctDNA) for longitudinal tumour monitoring in pancreatic ductal adenocarcinoma (PDAC) has not been explored beyond mutations in the KRAS proto-oncogene. Here, we aimed to characterise and track patient-specific somatic ctDNA variants, to assess longitudinal changes in disease burden and explore the landscape of actionable alterations.
Original languageEnglish
JournalBMC Cancer
Volume22
Issue number1
DOIs
Publication statusPublished - 7 Apr 2022

Keywords / Materials (for Non-textual outputs)

  • biomarkers
  • circulating tumour DNA
  • liquid biopsy
  • monitoring

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