TY - JOUR
T1 - Lose the fear and boost the everyday memory through memory destabilisation and reconsolidation
AU - Wang, Szu-han
N1 - Funding Information:
The author would like to acknowledge funding from Alzheimer’s Research UK (senior research fellowship and Ph.D. scholarship) and Biotechnology and Biological Sciences Research Council , and training provided by Prof Karim Nader, which continues to shape her and many other trainees’ careers.
Publisher Copyright:
© 2022 The Authors
PY - 2022/11
Y1 - 2022/11
N2 - This review starts with a brief description of key findings from Nader et al. (2000) which stimulate vibrant research of memory reconsolidation in the new millennium. It then zooms in to two aspects of the process that have important implications on whether a memory is susceptible to reconsolidation interference. First, memory strength contributes to a boundary condition on reconsolidation. The relevant receptor and circuit mechanisms are reviewed. Second, reactivation procedures affect memory destabilisation and memory susceptibility to reconsolidation interference. Recent null findings are briefly mentioned. Finally, it covers current discoveries of ‘tagging along’ reconsolidation to boost memory persistence. This review primarily focuses on evidence from fear conditioning paradigms, as interfering reconsolidation of fear memory paves ways for treating post-traumatic stress disorder (PTSD). Hippocampal-dependent spatial memories and reconsolidation are then discussed, as this approach provides crucial implications in boosting everyday memory persistence and insights on improving cognitive functions in aging.
AB - This review starts with a brief description of key findings from Nader et al. (2000) which stimulate vibrant research of memory reconsolidation in the new millennium. It then zooms in to two aspects of the process that have important implications on whether a memory is susceptible to reconsolidation interference. First, memory strength contributes to a boundary condition on reconsolidation. The relevant receptor and circuit mechanisms are reviewed. Second, reactivation procedures affect memory destabilisation and memory susceptibility to reconsolidation interference. Recent null findings are briefly mentioned. Finally, it covers current discoveries of ‘tagging along’ reconsolidation to boost memory persistence. This review primarily focuses on evidence from fear conditioning paradigms, as interfering reconsolidation of fear memory paves ways for treating post-traumatic stress disorder (PTSD). Hippocampal-dependent spatial memories and reconsolidation are then discussed, as this approach provides crucial implications in boosting everyday memory persistence and insights on improving cognitive functions in aging.
U2 - 10.1016/j.brainresbull.2022.09.019
DO - 10.1016/j.brainresbull.2022.09.019
M3 - Article
SN - 0361-9230
VL - 190
SP - 134
EP - 139
JO - Brain Research Bulletin
JF - Brain Research Bulletin
ER -