Loss of WWOX expression in gastric carcinoma

Rami I Aqeilan, Tamotsu Kuroki, Yuri Pekarsky, Omar Albagha, Francesco Trapasso, Raffaele Baffa, Kay Huebner, Pamela Edmonds, Carlo M Croce

Research output: Contribution to journalArticlepeer-review


WW domain-containing oxidoreductase (WWOX) is a tumor suppressor gene that maps to the common fragile site FRA16D on chromosome 16q23.3-24.1. To investigate the role of the WWOX gene in the development of gastric carcinoma, we examined a large series of primary adenocarcinomas and nine gastric cancer cell lines for the expression of Wwox.
Original languageEnglish
Pages (from-to)3053-8
Number of pages6
JournalClinical Cancer Research
Issue number9
Publication statusPublished - 1 May 2004


  • Adenocarcinoma
  • DNA Mutational Analysis
  • DNA, Neoplasm
  • Humans
  • Immunohistochemistry
  • Loss of Heterozygosity
  • Mutation
  • Oxidoreductases
  • RNA, Neoplasm
  • Reverse Transcriptase Polymerase Chain Reaction
  • Stomach
  • Stomach Neoplasms
  • Tumor Suppressor Proteins


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