Loss of WWOX expression in gastric carcinoma

Rami I Aqeilan; Tamotsu Kuroki; Yuri Pekarsky; Omar Albagha; Francesco Trapasso; Raffaele Baffa; Kay Huebner; Pamela Edmonds; Carlo M Croce

Loss of WWOX expression in gastric carcinoma

Rami I Aqeilan, Tamotsu Kuroki, Yuri Pekarsky, Omar Albagha, Francesco Trapasso, Raffaele Baffa, Kay Huebner, Pamela Edmonds, Carlo M Croce

Research output: Contribution to journal › Article › peer-review

Abstract

WW domain-containing oxidoreductase (WWOX) is a tumor suppressor gene that maps to the common fragile site FRA16D on chromosome 16q23.3-24.1. To investigate the role of the WWOX gene in the development of gastric carcinoma, we examined a large series of primary adenocarcinomas and nine gastric cancer cell lines for the expression of Wwox.

Original language	English
Pages (from-to)	3053-8
Number of pages	6
Journal	Clinical Cancer Research
Volume	10
Issue number	9
Publication status	Published - 1 May 2004

Keywords / Materials (for Non-textual outputs)

Adenocarcinoma
DNA Mutational Analysis
DNA, Neoplasm
Humans
Immunohistochemistry
Loss of Heterozygosity
Mutation
Oxidoreductases
RNA, Neoplasm
Reverse Transcriptase Polymerase Chain Reaction
Stomach
Stomach Neoplasms
Tumor Suppressor Proteins

Cite this

@article{e85432aa3f36469db9da9b6a8f77743f,

title = "Loss of WWOX expression in gastric carcinoma",

abstract = "WW domain-containing oxidoreductase (WWOX) is a tumor suppressor gene that maps to the common fragile site FRA16D on chromosome 16q23.3-24.1. To investigate the role of the WWOX gene in the development of gastric carcinoma, we examined a large series of primary adenocarcinomas and nine gastric cancer cell lines for the expression of Wwox.",

keywords = "Adenocarcinoma, DNA Mutational Analysis, DNA, Neoplasm, Humans, Immunohistochemistry, Loss of Heterozygosity, Mutation, Oxidoreductases, RNA, Neoplasm, Reverse Transcriptase Polymerase Chain Reaction, Stomach, Stomach Neoplasms, Tumor Suppressor Proteins",

author = "Aqeilan, \{Rami I\} and Tamotsu Kuroki and Yuri Pekarsky and Omar Albagha and Francesco Trapasso and Raffaele Baffa and Kay Huebner and Pamela Edmonds and Croce, \{Carlo M\}",

year = "2004",

month = may,

day = "1",

language = "English",

volume = "10",

pages = "3053--8",

journal = "Clinical Cancer Research",

issn = "1078-0432",

publisher = "American Association for Cancer Research Inc.",

number = "9",

}

TY - JOUR

T1 - Loss of WWOX expression in gastric carcinoma

AU - Aqeilan, Rami I

AU - Kuroki, Tamotsu

AU - Pekarsky, Yuri

AU - Albagha, Omar

AU - Trapasso, Francesco

AU - Baffa, Raffaele

AU - Huebner, Kay

AU - Edmonds, Pamela

AU - Croce, Carlo M

PY - 2004/5/1

Y1 - 2004/5/1

N2 - WW domain-containing oxidoreductase (WWOX) is a tumor suppressor gene that maps to the common fragile site FRA16D on chromosome 16q23.3-24.1. To investigate the role of the WWOX gene in the development of gastric carcinoma, we examined a large series of primary adenocarcinomas and nine gastric cancer cell lines for the expression of Wwox.

AB - WW domain-containing oxidoreductase (WWOX) is a tumor suppressor gene that maps to the common fragile site FRA16D on chromosome 16q23.3-24.1. To investigate the role of the WWOX gene in the development of gastric carcinoma, we examined a large series of primary adenocarcinomas and nine gastric cancer cell lines for the expression of Wwox.

KW - Adenocarcinoma

KW - DNA Mutational Analysis

KW - DNA, Neoplasm

KW - Humans

KW - Immunohistochemistry

KW - Loss of Heterozygosity

KW - Mutation

KW - Oxidoreductases

KW - RNA, Neoplasm

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Stomach

KW - Stomach Neoplasms

KW - Tumor Suppressor Proteins

M3 - Article

C2 - 15131042

SN - 1078-0432

VL - 10

SP - 3053

EP - 3058

JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 9

ER -

Loss of WWOX expression in gastric carcinoma

Abstract

Keywords / Materials (for Non-textual outputs)

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