Projects per year
Abstract / Description of output
application to studies of protein-protein interactions by Forster resonance energy transfer (FRET), which
are otherwise difficult or impossible to analyse . Time-correlated single photon counting (TCSPC) has
the best signal to noise ratio of any fluorescence lifetime technique  but cannot readily be implemented
within a cytometer due to the requirement of complex software algorithms, severely restricting the
throughput and preventing real-time sorting of cells .
The SiPM is a single-chip silicon photomultiplier detector employing a CMOS single-photon avalanche
diode (SPAD) array light detector and time to digital converters (TDCs) . The sensor's pile-up resistant
embedded centre of mass (CMM) processor accomplishes low-latency measurement and thresholding of
fluorescence lifetime. A digital control signal is generated with a maximum 16.6μs latency for cell sorter
|Number of pages||1|
|Publication status||Published - 26 Jun 2015|
|Event||Congress of International Society for the Advancement of Cytometry (CYTO) - Glasgow, United Kingdom|
Duration: 26 Jun 2015 → 30 Sept 2015
|Conference||Congress of International Society for the Advancement of Cytometry (CYTO)|
|Period||26/06/15 → 30/09/15|
FingerprintDive into the research topics of 'Low-Latency Time-Resolved Fluorescence Lifetime Flow Cytometry and Cell Sorting using a CMOS Silicon Photomultiplier'. Together they form a unique fingerprint.
- 2 Finished
1/10/13 → 31/03/19
Henderson, R. & Ameer-Beg, S.
1/10/11 → 30/09/14