Lsh regulates LTR retrotransposon repression independently of Dnmt3b function

Donncha S Dunican; Hazel A Cruickshanks; Masako Suzuki; Colin A Semple; Tracey Davey; Robert J Arceci; John Greally; Ian R Adams; Richard R Meehan

doi:10.1186/gb-2013-14-12-r146

Lsh regulates LTR retrotransposon repression independently of Dnmt3b function

Donncha S Dunican, Hazel A Cruickshanks, Masako Suzuki, Colin A Semple, Tracey Davey, Robert J Arceci, John Greally, Ian R Adams, Richard R Meehan

Research output: Contribution to journal › Article › peer-review

Abstract

DNA methylation contributes to genomic integrity by suppressing repeat-associated transposition. In addition to the canonical DNA methyltransferases, several auxillary chromatin factors are required to maintain DNA methylation at intergenic and satellite repeats. The interaction between Lsh, a chromatin helicase, and the de novo methyltransferase Dnmt3b facilitates deposition of DNA methylation at stem cell genes, which are hypomethylated in Lsh-/- embryos. We wished to determine if a similar targeting mechanism operates to maintain DNA methylation at repetitive sequences.

Original language	English
Pages (from-to)	R146
Journal	Genome Biology
Volume	14
Issue number	12
DOIs	https://doi.org/10.1186/gb-2013-14-12-r146
Publication status	Published - 24 Dec 2013

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10.1186/gb-2013-14-12-r146

Lsh regulates LTR retrotransposon repression independently of Dnmt3b function
© 2013 Dunican et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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title = "Lsh regulates LTR retrotransposon repression independently of Dnmt3b function",

abstract = "DNA methylation contributes to genomic integrity by suppressing repeat-associated transposition. In addition to the canonical DNA methyltransferases, several auxillary chromatin factors are required to maintain DNA methylation at intergenic and satellite repeats. The interaction between Lsh, a chromatin helicase, and the de novo methyltransferase Dnmt3b facilitates deposition of DNA methylation at stem cell genes, which are hypomethylated in Lsh-/- embryos. We wished to determine if a similar targeting mechanism operates to maintain DNA methylation at repetitive sequences.",

author = "Dunican, {Donncha S} and Cruickshanks, {Hazel A} and Masako Suzuki and Semple, {Colin A} and Tracey Davey and Arceci, {Robert J} and John Greally and Adams, {Ian R} and Meehan, {Richard R}",

note = "Research in RRMs laboratory is supported by the Medical Research Council, IMI-MARCAR and the BBSRC. ",

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AU - Dunican, Donncha S

AU - Cruickshanks, Hazel A

AU - Suzuki, Masako

AU - Semple, Colin A

AU - Davey, Tracey

AU - Arceci, Robert J

AU - Greally, John

AU - Adams, Ian R

AU - Meehan, Richard R

N1 - Research in RRMs laboratory is supported by the Medical Research Council, IMI-MARCAR and the BBSRC.

PY - 2013/12/24

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N2 - DNA methylation contributes to genomic integrity by suppressing repeat-associated transposition. In addition to the canonical DNA methyltransferases, several auxillary chromatin factors are required to maintain DNA methylation at intergenic and satellite repeats. The interaction between Lsh, a chromatin helicase, and the de novo methyltransferase Dnmt3b facilitates deposition of DNA methylation at stem cell genes, which are hypomethylated in Lsh-/- embryos. We wished to determine if a similar targeting mechanism operates to maintain DNA methylation at repetitive sequences.

AB - DNA methylation contributes to genomic integrity by suppressing repeat-associated transposition. In addition to the canonical DNA methyltransferases, several auxillary chromatin factors are required to maintain DNA methylation at intergenic and satellite repeats. The interaction between Lsh, a chromatin helicase, and the de novo methyltransferase Dnmt3b facilitates deposition of DNA methylation at stem cell genes, which are hypomethylated in Lsh-/- embryos. We wished to determine if a similar targeting mechanism operates to maintain DNA methylation at repetitive sequences.

U2 - 10.1186/gb-2013-14-12-r146

DO - 10.1186/gb-2013-14-12-r146

M3 - Article

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SN - 1465-6906

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SP - R146

JO - Genome Biology

JF - Genome Biology

IS - 12

ER -

Lsh regulates LTR retrotransposon repression independently of Dnmt3b function

Abstract

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