Lung Eosinophils – a Novel ‘Virus Sink’ that is Defective in Asthma?

Milos Jesenak, Jurgen Schwarze

Research output: Contribution to journalArticlepeer-review

Abstract

Eosinophils represent one of the most studied cells in the development and pathophysiology of various immune mediated disorders and conditions. Moreover, they serve as important biomarkers (diagnostic, therapy‐driving, prognostic) in daily allergy praxis and can be affected by several therapeutic interventions.1 Eosinophils differentiate from a pluripotent progenitor under the influence of several cytokines and growth factors. Amongst these, interleukin‐5 (IL‐5) seems to be critical for eosinophil differentiation and maturation in the bone marrow. After reaching maturity, eosinophils enter the circulation and in response to stimuli such as eotaxins, they migrate into the tissues.
Original languageEnglish
JournalAllergy
Early online date10 Apr 2019
DOIs
Publication statusE-pub ahead of print - 10 Apr 2019

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