Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis

Michael A Gibbons; Alison C MacKinnon; Prakash Ramachandran; Kevin Dhaliwal; Rodger Duffin; Alexander T Phythian-Adams; Nico van Rooijen; Christopher Haslett; Sarah E Howie; A John Simpson; Nikhil Hirani; Jack Gauldie; John P Iredale; Tariq Sethi; Stuart J Forbes

doi:10.1164/rccm.201010-1719OC

Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis

Michael A Gibbons, Alison C MacKinnon, Prakash Ramachandran, Kevin Dhaliwal, Rodger Duffin, Alexander T Phythian-Adams, Nico van Rooijen, Christopher Haslett, Sarah E Howie, A John Simpson, Nikhil Hirani, Jack Gauldie, John P Iredale, Tariq Sethi, Stuart J Forbes

Research output: Contribution to journal › Article › peer-review

Abstract

Idiopathic pulmonary fibrosis (IPF) is a devastating disease. Antiinflammatory therapies, including corticosteroids, are of no benefit. The role of monocytes and macrophages is therefore controversial.

Original language	English
Pages (from-to)	569-81
Number of pages	13
Journal	American Journal of Respiratory and Critical Care Medicine
Volume	184
Issue number	5
DOIs	https://doi.org/10.1164/rccm.201010-1719OC
Publication status	Published - 2011

Keywords / Materials (for Non-textual outputs)

immune cells
antiinflammatory
corticosteroids

Access to Document

10.1164/rccm.201010-1719OC

http://www.atsjournals.org/doi/abs/10.1164/rccm.201010-1719OC#.VC0QEBAkRBk

Autologous macrophage therapy promotes stem cell-mediated liver regeneration: a novel therapy for end-stage liver disease
Forbes, S. (Principal Investigator) & Iredale, J. (Co-investigator)
MRC
1/02/11 → 30/09/14
Project: Research
Monocyte-based gene therapy for acute neutrophil-medicated tissue injury
Dhaliwal, K. (Principal Investigator) & Simpson, J. (Co-investigator)
MRC
1/02/08 → 31/01/10
Project: Research
The functional role of macrophages in the progression and resolution of lung fibrosis
Forbes, S. (Principal Investigator), Iredale, J. (Co-investigator) & Sethi, T. (Co-investigator)
MRC
15/05/07 → 31/07/10
Project: Research

Cite this

Gibbons, M. A., MacKinnon, A. C., Ramachandran, P., Dhaliwal, K., Duffin, R., Phythian-Adams, A. T., van Rooijen, N., Haslett, C., Howie, S. E., Simpson, A. J., Hirani, N., Gauldie, J., Iredale, J. P., Sethi, T., & Forbes, S. J. (2011). Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis. American Journal of Respiratory and Critical Care Medicine, 184(5), 569-81. https://doi.org/10.1164/rccm.201010-1719OC

@article{b0d2cdf87acf4c4dbfac93e5a5e5f144,

title = "Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis",

abstract = "Idiopathic pulmonary fibrosis (IPF) is a devastating disease. Antiinflammatory therapies, including corticosteroids, are of no benefit. The role of monocytes and macrophages is therefore controversial.",

keywords = "immune cells, antiinflammatory, corticosteroids",

author = "Gibbons, \{Michael A\} and MacKinnon, \{Alison C\} and Prakash Ramachandran and Kevin Dhaliwal and Rodger Duffin and Phythian-Adams, \{Alexander T\} and \{van Rooijen\}, Nico and Christopher Haslett and Howie, \{Sarah E\} and Simpson, \{A John\} and Nikhil Hirani and Jack Gauldie and Iredale, \{John P\} and Tariq Sethi and Forbes, \{Stuart J\}",

year = "2011",

doi = "10.1164/rccm.201010-1719OC",

language = "English",

volume = "184",

pages = "569--81",

journal = "American Journal of Respiratory and Critical Care Medicine",

issn = "1535-4970",

publisher = "American Thoracic Society",

number = "5",

}

Gibbons, MA, MacKinnon, AC, Ramachandran, P , Dhaliwal, K , Duffin, R, Phythian-Adams, AT, van Rooijen, N, Haslett, C, Howie, SE, Simpson, AJ, Hirani, N, Gauldie, J, Iredale, JP, Sethi, T & Forbes, SJ 2011, 'Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis', American Journal of Respiratory and Critical Care Medicine, vol. 184, no. 5, pp. 569-81. https://doi.org/10.1164/rccm.201010-1719OC

TY - JOUR

T1 - Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis

AU - Gibbons, Michael A

AU - MacKinnon, Alison C

AU - Ramachandran, Prakash

AU - Dhaliwal, Kevin

AU - Duffin, Rodger

AU - Phythian-Adams, Alexander T

AU - van Rooijen, Nico

AU - Haslett, Christopher

AU - Howie, Sarah E

AU - Simpson, A John

AU - Hirani, Nikhil

AU - Gauldie, Jack

AU - Iredale, John P

AU - Sethi, Tariq

AU - Forbes, Stuart J

PY - 2011

Y1 - 2011

N2 - Idiopathic pulmonary fibrosis (IPF) is a devastating disease. Antiinflammatory therapies, including corticosteroids, are of no benefit. The role of monocytes and macrophages is therefore controversial.

AB - Idiopathic pulmonary fibrosis (IPF) is a devastating disease. Antiinflammatory therapies, including corticosteroids, are of no benefit. The role of monocytes and macrophages is therefore controversial.

KW - immune cells

KW - antiinflammatory

KW - corticosteroids

U2 - 10.1164/rccm.201010-1719OC

DO - 10.1164/rccm.201010-1719OC

M3 - Article

C2 - 21680953

SN - 1535-4970

VL - 184

SP - 569

EP - 581

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

IS - 5

ER -

Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis

Abstract

Keywords / Materials (for Non-textual outputs)

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Projects

Autologous macrophage therapy promotes stem cell-mediated liver regeneration: a novel therapy for end-stage liver disease

Monocyte-based gene therapy for acute neutrophil-medicated tissue injury

The functional role of macrophages in the progression and resolution of lung fibrosis

Cite this