Lymphocyte subpopulations in the blood of sheep persistently infected with border disease virus

C Burrells, P F Nettleton, H. W. Reid, H R Miller, John Hopkins, I. McConnell, M D Gorrell, M R Brandon

Research output: Contribution to journalArticlepeer-review

Abstract

The surface phenotypes of peripheral blood lymphocytes in groups of lambs and adult sheep persistently infected with Border disease virus (P-I BD) were compared with those of healthy controls. The proportion and number of lymphocytes bearing surface immunoglobulin (sIg+) and expressing class II MHC antigen (B cells) were significantly increased. A significant increase in CD1+ lymphocytes was also evident. Conversely, the proportion of T lymphocytes in P-I BD lambs was reduced. A marked reduction in the proportion of circulating lymphocytes expressing class I MHC antigen was also observed. These findings were not affected by differences in the strain of the virus responsible for the persistent infection.
Original languageEnglish
Pages (from-to)446-51
Number of pages6
JournalClinical & Experimental Immunology
Volume76
Issue number3
Publication statusPublished - Jun 1989

Keywords

  • Aging/immunology
  • Animals
  • Antibodies, Monoclonal
  • B-Lymphocytes
  • Border Disease/blood
  • Border Disease/immunology
  • Leukocyte Count
  • Lymphocytes/classification
  • Phenotype
  • Sheep
  • Sheep Diseases/immunology
  • T-Lymphocytes/classification

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