Lymphocytes in pseudomembranes of late prosthetic joint failure

D M Salter, A S Krajewski, S Robertson

Research output: Contribution to journalArticlepeer-review


The pseudomembrane formed in association with late aseptic prosthesis failure contains a mixed giant cell and histiocytic infiltrate with variable numbers of lymphocytes. Immunolabelling with a panel of antibodies on paraffin sections was undertaken to define the nature of the lymphoid infiltrate in 19 cases. In all cases, the predominant lymphoid cell was a memory (CD45RO+, CD45RA-) T-cell. B-cells were rare. Tissue from patients with rheumatoid arthritis (RA) contained greater numbers of T-cells when compared with patients with osteoarthritis (OA), suggesting that the intensity of the lymphoid infiltrates reflects the underlying joint disease rather than necessarily being part of a hypersensitivity response to wear debris.

Original languageEnglish
Pages (from-to)271-5
Number of pages5
JournalThe Journal of Pathology
Issue number3
Publication statusPublished - Mar 1992


  • Aged
  • Antigens
  • Equipment Failure
  • Female
  • Humans
  • Immunologic Techniques
  • Joint Prosthesis
  • Joints
  • Lymphocytes
  • Male
  • Membranes
  • Middle Aged
  • Staining and Labeling
  • T-Lymphocytes


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