Machine learning and wearable sensors for automated Parkinson’s disease diagnosis aid: a systematic review

Background: The diagnosis of Parkinson’s disease is currently based on clinical evaluation. Despite clinical hallmarks, unfortunately, the error rate is still significant. Low in-vivo diagnostic accuracy of clinical evaluation mainly relies on the lack of quantitative biomarkers for an objective motor performance assessment. Non-invasive technologies, such as wearable sensors, coupled with machine learning algorithms, assess quantitatively and objectively the motor performances, with possible benefits either for in-clinic and at-home settings. We conducted a systematic review of the literature on machine learning algorithms embedded in smart devices in Parkinson’s disease diagnosis. Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we searched PubMed for articles published between December, 2007 and July, 2023, using a search string combining “Parkinson’s disease” AND (“healthy” or “control”) AND “diagnosis”, within the Groups and Outcome domains. Additional search terms included “Algorithm”, “Technology” and “Performance”. Results: From 89 identified studies, 47 met the inclusion criteria based on the search string and four additional studies were included based on the Authors’ expertise. Gait emerged as the most common parameter analysed by machine learning models, with Support Vector Machines as the prevalent algorithm. The results suggest promising accuracy with complex algorithms like Random Forest, Support Vector Machines, and K-Nearest Neighbours. Discussion: Despite the promise shown by machine learning algorithms, real-world applications may still face limitations. This review suggests that integrating machine learning with wearable sensors has the potential to improve Parkinson’s disease diagnosis. These tools could provide clinicians with objective data, potentially aiding in earlier detection.