Macrophage chemotaxis to apoptotic Burkitt's lymphoma cells in vitro: role of CD14 and CD36

Lucy A Truman, Carol Anne Ogden, Sarah E M Howie, Christopher D Gregory

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

In Burkitt's lymphoma (BL), apoptosis occurs at high frequency alongside uncontrolled proliferation. Macrophages infiltrate these tumours in large numbers and engage in the phagocytic clearance of apoptotic cells in situ. Here we tested the hypothesis that apoptosis of BL cells may provide a mechanism for recruitment of macrophages to these tumours. We show that monocytes and macrophages, but not neutrophils, preferentially migrated to apoptotic BL cells in vitro. Transfection of BL cells with the anti-apoptotic gene bcl-2 both prevented apoptosis and abolished macrophage chemotaxis. Macrophage migration to BL populations correlated well with the number of apoptotic BL cells present (the Pearson correlation r = 0.81, p
Original languageEnglish
Pages (from-to)21-30
Number of pages10
Issue number1-2
Publication statusPublished - 2004

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Antigens, CD14
  • Antigens, CD36
  • Apoptosis
  • Burkitt Lymphoma
  • Cells, Cultured
  • Chemotaxis
  • Flow Cytometry
  • Humans
  • Macrophages
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Tumor Cells, Cultured
  • Up-Regulation


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