TY - JOUR
T1 - Macrophage diversity enhances tumor progression and metastasis
AU - Qian, Binzhi
AU - Pollard, Jeffrey W
N1 - Copyright 2010 Elsevier Inc. All rights reserved.
PY - 2010
Y1 - 2010
N2 - There is persuasive clinical and experimental evidence that macrophages promote cancer initiation and malignant progression. During tumor initiation, they create an inflammatory environment that is mutagenic and promotes growth. As tumors progress to malignancy, macrophages stimulate angiogenesis, enhance tumor cell migration and invasion, and suppress antitumor immunity. At metastatic sites, macrophages prepare the target tissue for arrival of tumor cells, and then a different subpopulation of macrophages promotes tumor cell extravasation, survival, and subsequent growth. Specialized subpopulations of macrophages may represent important new therapeutic targets.
AB - There is persuasive clinical and experimental evidence that macrophages promote cancer initiation and malignant progression. During tumor initiation, they create an inflammatory environment that is mutagenic and promotes growth. As tumors progress to malignancy, macrophages stimulate angiogenesis, enhance tumor cell migration and invasion, and suppress antitumor immunity. At metastatic sites, macrophages prepare the target tissue for arrival of tumor cells, and then a different subpopulation of macrophages promotes tumor cell extravasation, survival, and subsequent growth. Specialized subpopulations of macrophages may represent important new therapeutic targets.
U2 - 10.1016/j.cell.2010.03.014
DO - 10.1016/j.cell.2010.03.014
M3 - Article
C2 - 20371344
SN - 0092-8674
VL - 141
SP - 39
EP - 51
JO - Cell
JF - Cell
IS - 1
ER -