Abstract
Dendritic cells have been considered an immune cell type that is specialized for the presentation of Ag to naive T cells. Considerable effort has been applied to separate their lineage, pathways of differentiation, and effectiveness in Ag presentation from those of macrophages. This review summarizes evidence that dendritic cells are a part of the mononuclear phagocyte system and are derived from a common precursor, responsive to the same growth factors (including CSF-1), express the same surface markers (including CD11c), and have no unique adaptation for Ag presentation that is not shared by other macrophages. The Journal of Immunology, 2008,181:5829-5835.
| Original language | English |
|---|---|
| Pages (from-to) | 5829-5835 |
| Number of pages | 7 |
| Journal | The Journal of Immunology |
| Volume | 181 |
| Issue number | 9 |
| Publication status | Published - 1 Nov 2008 |
Keywords / Materials (for Non-textual outputs)
- Animals
- Antigen-Presenting Cells/cytology
- Antigen-Presenting Cells/immunology
- Antigen-Presenting Cells/metabolism
- Biological Markers/metabolism
- Cell Differentiation/genetics
- Cell Differentiation/immunology
- Cell Lineage/genetics
- Cell Lineage/immunology
- Dendritic Cells/cytology
- Dendritic Cells/immunology
- Dendritic Cells/metabolism
- Humans
- Macrophages/cytology
- Macrophages/immunology
- Macrophages/metabolism
- Mice