Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation state

D A Hume, D M Underhill, M J Sweet, A O Ozinsky, F Y Liew, A Aderem

Research output: Contribution to journalArticlepeer-review

Abstract

Macrophages sense microorganisms through activation of members of the Toll-like receptor family, which initiate signals linked to transcription of many inflammation associated genes. In this paper we examine whether the signal from Toll-like receptors [TLRs] is sustained for as long as the ligand is present, and whether responses to different TLR agonists are additive.
Original languageEnglish
Pages (from-to)11
JournalBMC Immunology
Volume2
Publication statusPublished - 2001

Keywords

  • Animals
  • Cell Line
  • Cells, Cultured
  • Cytokines
  • Dose-Response Relationship, Drug
  • Genes, Reporter
  • Kinetics
  • Lipopolysaccharides
  • Luciferases
  • Macrophage Activation
  • Macrophages
  • Membrane Glycoproteins
  • Mice
  • Mice, Inbred BALB C
  • Receptors, Cell Surface
  • Toll-Like Receptor 2
  • Toll-Like Receptor 4
  • Toll-Like Receptors

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